Condition

Rectal Cancer, Adenocarcinoma clinical trials and research

• 6Clinical trials
• 1New in 30 days
• 6Countries

Newest Rectal Cancer, Adenocarcinoma clinical trials

All recruiting trials (6)

• Neoadjuvant therapy for locally advanced low rectal cancer: adding fruquintinib to short-course radiotherapy with tislelizumab and CAPOX

  This study tests whether adding fruquintinib to short-course radiotherapy plus tislelizumab and CAPOX before surgery helps people with locally advanced low rectal cancer achieve a better tumor response.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, Shanghai Municipality · NCT07888309

• HDR endorectal brachytherapy with 3D-printed guidance and shielding for organ-preserving rectal cancer

  This study tests an organ-preserving radiotherapy approach for localized rectal adenocarcinoma in patients who can’t have radical surgery or choose not to, using external beam radiotherapy followed by targeted HDR endorectal brachytherapy with a custom 3D-printed guide and shielding.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07786493

• Short-course radiation followed by liposomal irinotecan, oxaliplatin, capecitabine and sintilimab before surgery for high-risk rectal cancer

  This treatment plan tests whether a short course of radiation followed by six cycles of liposomal irinotecan, oxaliplatin, capecitabine and the immunotherapy drug sintilimab before surgery can shrink tumors and let some people with newly diagnosed high-risk, locally advanced rectal cancer avoid immediate surgery.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT07474103

• Adding tislelizumab with or without the probiotic Probio-M9 to pre-surgery chemoradiation for pMMR/MSS locally advanced rectal cancer.

  This will see if adding the PD-1 drug tislelizumab, with or without the probiotic Probio-M9, to standard pre-surgery chemoradiation helps adults with pMMR/MSS locally advanced rectal cancer.

  Recruiting Phase 2 Seventh Medical Center of PLA General Hospital · Beijing, Beijing Municipality · NCT07458529

• First-line trastuzumab-deruxtecan with capecitabine and bevacizumab for HER2-positive metastatic colorectal cancer

  This trial tests whether giving trastuzumab-deruxtecan together with capecitabine and bevacizumab as first treatment helps people with HER2-positive metastatic or unresectable colorectal cancer shrink tumors and respond better.

  Recruiting at 28 sites Phase 2 Gruppo Oncologico del Nord-Ovest · Lyon and 27 other locations · NCT07407465

• Modulating gut bacteria with antibiotics for rectal cancer treatment

  This study is testing if using an antibiotic to change gut bacteria can help people with advanced rectal cancer respond better to radiation treatment.

  Recruiting Phase 2 AC Camargo Cancer Center · São Paulo, São Paulo · NCT06793137

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Quick answers

How many Rectal Cancer, Adenocarcinoma clinical trials are recruiting right now?

6, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in China (4 trials), France (1 trial), Germany (1 trial), Italy (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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