Condition

RAS Mutation clinical trials and research

• 11Clinical trials
• 7Countries

Newest RAS Mutation clinical trials

All recruiting trials (11)

• BG-85738 alone or with other anticancer drugs in RAS-mutant advanced or metastatic solid tumors

  This study tests BG-85738, alone or with other cancer drugs, in adults whose solid tumors have RAS mutations and have progressed.

  Recruiting at 3 sites Phase 1 BeOne Medicines · South Brisbane, Queensland and 2 other locations · NCT07746141

• AN4035 in advanced cancers with RAS mutations and high CEACAM5 expression

  This first-in-human trial tests AN4035 to see if it is safe, tolerable, and possibly active in people with RAS-mutated, CEACAM5-positive advanced solid tumors, including when given with cetuximab.

  Recruiting at 2 sites Phase 1 Adlai Nortye Biopharma Co., Ltd. · Perth and 1 other locations · NCT07686445

• GFH276 with Cetuximab or chemotherapy in RAS-mutated solid tumors and PDAC

  This study tests whether GFH276 combined with cetuximab or standard chemotherapy can help adults with advanced solid tumors or pancreatic cancer that carry a RAS mutation.

  Recruiting at 10 sites Phase 1/2 Genfleet Therapeutics (Shanghai) Inc. · Concord, New South Wales and 16 other locations · NCT07678593

• Oral AN9025 for advanced solid tumors with RAS mutations

  This trial tests whether the oral drug AN9025 is safe and tolerable for adults with advanced solid tumors that have RAS mutations.

  Recruiting at 2 sites Phase 1 Adlai Nortye Biopharma Co., Ltd. · Orlando, Florida and 2 other locations · NCT07252479

• TNG462 combined with RAS inhibitors or chemotherapy for MTAP‑loss pancreatic and RAS‑mutant lung cancer

  This trial will test whether taking oral TNG462 together with RAS inhibitors or standard chemotherapy is safe and helps people with MTAP‑loss pancreatic cancer or RAS‑mutant non‑small cell lung cancer.

  Recruiting at 18 sites Phase 1/2 Tango Therapeutics, Inc. · Scottsdale, Arizona and 17 other locations · NCT06922591

• Combination treatment for metastatic colorectal cancer

  This study is testing a combination of three drugs to see if it can help patients with certain types of metastatic colorectal cancer who have previously responded well to similar treatments.

  Recruiting Phase 2 Beijing Hospital · Beijing, Beijing Municipality · NCT06321081

• Testing PAS-004 for patients with advanced solid tumors

  This study is testing a new oral medication called PAS-004 to see if it is safe and tolerable for people with advanced solid tumors that have certain genetic mutations.

  Recruiting at 5 sites Phase 1 Pasithea Therapeutics Corp. · San Antonio, Texas and 4 other locations · NCT06299839

• Combination treatment for advanced colorectal cancer

  This study is testing a new combination treatment for people with advanced colorectal cancer to see if it helps them live longer without their cancer getting worse.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06218810

• Treatment of advanced cancers with RSC-1255

  This study is testing a new oral drug called RSC-1255 to see if it can help adults with advanced cancers that haven't responded to other treatments.

  Recruiting at 3 sites Phase 1 RasCal Therapeutics, Inc. · Los Angeles, California and 2 other locations · NCT04678648

• Collection of bio-specimens from patients with RASopathies

  This study is collecting samples from people with RASopathies to help researchers learn more about these rare genetic disorders and how they affect the body.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT04395495

• Analyzing blood abnormalities in children with RAS mutations

  This study looks at blood issues in children with RAS mutations to see how these problems develop over time and to help improve their care.

  Recruiting at 14 sites Assistance Publique - Hôpitaux de Paris · Angers and 13 other locations · NCT04286360

Related topics

Quick answers

How many RAS Mutation clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (5 trials), China (3 trials), Australia (3 trials), New Zealand (1 trial), Bulgaria (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 2: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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