Condition

Prosthetic Joint Infection clinical trials and research

• 15Clinical trials
• 1NIH research projects
• 8Countries

Newest Prosthetic Joint Infection clinical trials

All recruiting trials (15)

• How knee and hip joint replacements are doing over time

  This observational study follows adults who have knee or hip replacements to see how their outcomes look over time after the surgery.

  Recruiting University Hospital, Bonn · Bonn, North Rhine-Westphalia · NCT07799818

• Population pharmacokinetics of rifampicin in staphylococcal osteoarticular infections

  This study tests how rifampicin behaves in the body of adults with staphylococcal osteoarticular infections when given with levofloxacin or ciprofloxacin, to see how drug exposure relates to tolerance and outcomes.

  Recruiting Groupe Hospitalier Diaconesses Croix Saint-Simon · Paris, Paris · NCT07788404

• Reducing bacterial contamination during primary shoulder replacement

  This trial tests whether putting Prontosan antimicrobial gel on the dermal layer after the skin is cut can lower Cutibacterium acnes growth in men having primary shoulder replacement.

  Recruiting St. Louis University · St Louis, Missouri · NCT07406893

• Methylene blue dye to measure how much irrigation clears contamination during knee replacement procedures

  We will test whether putting methylene blue dye into the knee during replacement or DAIR procedures can show how much irrigation is needed to wash out contaminants.

  Recruiting Phase 1 University of Miami · Miami, Florida · NCT07324954

• PLG0206 irrigation to prevent repeat knee replacement infections after DAIR

  This will test if washing the knee with PLG0206 during a DAIR procedure can lower the chance that a prosthetic knee infection comes back in adults who had a knee replacement.

  Recruiting at 19 sites Phase 2/3 Peptilogics · Sarasota, Florida and 20 other locations · NCT07214311

• Prosthetic joint infection patterns in critically ill patients who died

  This project looks at health records of adults who died in intensive care with a hip, knee, or shoulder prosthetic joint infection from 2018–2022 to see common care paths and outcomes.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, France · NCT07107685

• Peri-operative probiotics to support immune recovery after hip or knee prosthetic joint infection

  This test adds a daily probiotic to usual surgery and antibiotics to see if it lowers immune markers and improves gut symptoms in adults treated for hip or knee prosthetic joint infection.

  Recruiting NYU Langone Health · New York, New York · NCT06919913

• Comparing two types of spacers for treating knee joint infections

  This study is testing which type of spacer works better for treating knee joint infections in patients who have had knee replacement surgery.

  Recruiting Northwestern University · Chicago, Illinois · NCT06293352

• Comparing two antibiotic treatments for joint infections caused by Staphylococcus

  This study tests whether a combination of two antibiotics can work better than just one to treat joint infections caused by Staphylococcus in adults with hip or knee infections.

  Recruiting at 11 sites Phase 4 Leiden University Medical Center · Leiden, Zuid Hollans and 12 other locations · NCT06172010

• Early prosthesis reimplantation for hip or knee joint infections

  This study is testing if putting a new hip or knee joint back in sooner after an infection can help patients recover faster and use their joint better compared to the usual waiting time.

  Recruiting at 2 sites University Hospital, Montpellier · Montpellier and 1 other locations · NCT05642013

• Using antibiotic-impregnated bone grafts to prevent infections in hip replacements

  This study is testing if using bone grafts soaked in antibiotics can help prevent infections in people getting hip replacements.

  Recruiting Phase 2 University Hospital, Linkoeping · Linköping, Region Östergotland · NCT05169229

• Long-term follow-up for hip prosthetic joint infections at University Hospitals Leuven

  This study looks at patients with hip joint infections after surgery to see how well different treatments work over time.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT05000723

• Evaluating diagnostic markers for joint infections in hip and knee surgeries

  This study is testing if certain blood and joint fluid markers can help doctors quickly and accurately diagnose joint infections in patients having hip or knee revision surgeries.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT04858217

• Observing the safety of phage therapy for serious infections

  This study is testing the safety of using phage therapy to treat serious infections, especially in people with prosthetic joints, by looking at any side effects that might happen.

  Recruiting Hospices Civils de Lyon · Lyon · NCT04650607

• Cohort of patients with prosthetic joint infections

  This study is tracking adults with prosthetic joint infections to see how different treatments affect their recovery and long-term health over two years.

  Recruiting Groupe Hospitalier Diaconesses Croix Saint-Simon · Paris, Île-de-France Region · NCT02801253

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Musculoskeletal tissue damage linked to prosthetic joint infection and a new protective drug

  A study in rats will test whether a new drug can protect bone and muscle from damage caused by prosthetic joint infection.

  NIH research West Virginia University · Morgantown, United States · NIH-11440186

Related topics

Quick answers

How many Prosthetic Joint Infection clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (5 trials), France (5 trials), Sweden (1 trial), Italy (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 4: 1, Phase 1: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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