Using antibiotic-impregnated bone grafts to prevent infections in hip replacements
Official title: Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement. The ABOGRAFT Trial
Run by University Hospital, Linkoeping · NCT05169229 · Data updated 2026-11-12
This study is testing if using bone grafts soaked in antibiotics can help prevent infections in people getting hip replacements.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1100 (estimated) |
| Sponsor | University Hospital, Linkoeping Academic / other |
| Locations | 1 site (Linköping, Region Östergotland) |
| Status | Recruiting |
| Started | April 1, 2022 |
| Main results expected | December 2028 |
| Study ends | December 2031 |
| Registry record updated | July 10, 2026 |
| Trial ID | NCT05169229 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who require hip arthroplasty and are willing to provide informed consent.
✕Probably not a fit
Patients with ongoing prosthetic joint infections or known allergies to the study antibiotics will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the use of antibiotic-impregnated bone grafts to reduce the risk of periprosthetic joint infections in patients undergoing total hip replacement. The study aims to evaluate the effectiveness of combining vancomycin and tobramycin with impacted morselized bone allograft in preventing infections, particularly in complex primary and revision surgeries. Participants will be monitored for two years to assess infection rates and overall outcomes following hip arthroplasty.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of infections following hip replacement surgeries, improving patient outcomes and quality of life.
How similar studies have gone: Previous studies have shown success with local antibiotic delivery methods in reducing postoperative infections, making this approach promising yet still requiring further investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years 2. Hip arthroplasty requiring bone graft 3. Willing to provide informed consent. 4. For women of childbearing potential; a negative pregnancy test prior to surgery. Exclusion Criteria: 1. Ongoing prosthetic joint infection 2. Known allergies and contraindications for the use of vancomycin or tobramycin 3. Mental inability, reluctance, or language difficulties that according to investigator judgement, result in difficulty understanding the meaning of study participation 4. Expected difficulties to complete 2-year follow-up 5. Females of child bearing potential not using contraception 6. Pregnant females 7. Nursing females
Where it's running
-
Universitetssjukhuset Linköping
Linköping, Region Östergotland, Sweden Recruiting
Study contacts
- Principal investigator: Jörg Schilcher, PhD — Linkoeping University
- Study coordinator: Daphne Wezenberg, PhD
- Email: daphne.wezenberg@liu.se
- Phone: 0046101030000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.