Understanding the early stages and progression of pulmonary fibrosis
Project 4: Defining the Molecular Natural History of Early and Progressive Pulmonary Fibrosis
This study is looking at how pulmonary fibrosis develops by examining tissue samples from people at risk for the condition, with the goal of finding new ways to diagnose and treat it better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10846188 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind pulmonary fibrosis (PF) using advanced techniques like single cell RNA-sequencing and spatial transcriptomics. By analyzing biopsy samples from individuals at risk for familial pulmonary fibrosis, the study aims to identify new cell types and understand how the disease develops over time. Patients will be involved in providing tissue samples, which will help researchers pinpoint when and how cellular changes occur in the disease process. This approach could lead to better diagnostic and therapeutic strategies for managing PF.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are at risk for familial pulmonary fibrosis or have early signs of the disease.
Not a fit: Patients with advanced pulmonary fibrosis or those not at risk for familial pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for pulmonary fibrosis.
How similar studies have performed: Previous research using similar molecular techniques has shown promise in understanding other fibrotic diseases, suggesting potential for success in this area as well.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Banovich, Nicholas Eli — University of Michigan at Ann Arbor
- Study coordinator: Banovich, Nicholas Eli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.