Understanding how lung fibrosis progresses at a molecular level
Official title: Molecular Regulation of Progressive Pulmonary Fibrosis
Funded at Cedars-Sinai Medical Center · NIH-11045656 · Data updated 2026-11-12
This study is looking at how a substance called hyaluronan affects lung inflammation and healing in people with progressive pulmonary fibrosis, with the hope of finding new ways to help improve lung health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | March 1, 2020 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $762,785 |
| NIH project number | 5R35HL150829-06 |
| Project ID | NIH-11045656 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with progressive pulmonary fibrosis or related lung conditions.
✕Less likely to help
Patients with acute lung injuries or those without a diagnosis of pulmonary fibrosis may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that contribute to progressive pulmonary fibrosis, a serious lung condition. The team focuses on the role of hyaluronan, a substance found in the body, and its receptors in lung inflammation and stem cell regeneration. By studying these interactions in both mice and human samples, the researchers aim to uncover why certain cells fail to regenerate and how this leads to persistent fibrosis. The ultimate goal is to identify potential therapeutic targets that could improve lung health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that halt or reverse the progression of pulmonary fibrosis, improving patients' quality of life.
How similar studies have gone: Previous research has shown promise in understanding lung fibrosis through similar molecular approaches, indicating potential for success in this area.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Noble, Paul Wesley — Cedars-Sinai Medical Center
- Study coordinator: Noble, Paul Wesley
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to progressive lung scarring
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-
p53 acetylation and alveolar stem cell aging in progressive lung fibrosis
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Support-T: a mobile tool to help people with progressive pulmonary fibrosis and their caregivers get palliative care and planning
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Defining how early pulmonary fibrosis develops at the molecular level
Researchers are studying early stages of pulmonary fibrosis at the molecule-by-molecule level to understand how the disease starts and progresses in people.
-
How lung cells change in early and worsening pulmonary fibrosis
Researchers will map how specific lung cells and their local neighborhoods change over time in people at risk for or with pulmonary fibrosis using advanced tissue-based gene mapping.
-
The effects of air pollution on progressive pulmonary fibrosis
This study is looking at how air pollution, especially tiny particles and nitrogen dioxide, might lead to a serious lung condition called progressive pulmonary fibrosis, particularly in people living in areas that are more vulnerable to pollution.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.