Understanding how lung fibrosis progresses at a molecular level
Molecular Regulation of Progressive Pulmonary Fibrosis
This study is looking at how a substance called hyaluronan affects lung inflammation and healing in people with progressive pulmonary fibrosis, with the hope of finding new ways to help improve lung health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11045656 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that contribute to progressive pulmonary fibrosis, a serious lung condition. The team focuses on the role of hyaluronan, a substance found in the body, and its receptors in lung inflammation and stem cell regeneration. By studying these interactions in both mice and human samples, the researchers aim to uncover why certain cells fail to regenerate and how this leads to persistent fibrosis. The ultimate goal is to identify potential therapeutic targets that could improve lung health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with progressive pulmonary fibrosis or related lung conditions.
Not a fit: Patients with acute lung injuries or those without a diagnosis of pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that halt or reverse the progression of pulmonary fibrosis, improving patients' quality of life.
How similar studies have performed: Previous research has shown promise in understanding lung fibrosis through similar molecular approaches, indicating potential for success in this area.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Noble, Paul Wesley — Cedars-Sinai Medical Center
- Study coordinator: Noble, Paul Wesley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.