Clinical trial Recruiting at 1 site Observational Ages 18 and up Women only

Does getting the labor pain relief you expect change postpartum depression risk?

Official title: Maternal Expectations on Labor Analgesia and Risk of Postpartum Depression: An Observational Study

Run by University of Padova · NCT07292649 · Data updated 2026-11-12

We will see if women whose expectations about labor pain relief are met during a planned vaginal birth are less likely to have postpartum depression.

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment3640 (estimated)
SponsorUniversity of Padova
Academic / other
Locations1 site (Padova, Veneto)
StatusRecruiting
StartedJanuary 8, 2026
Main results expectedJanuary 2029
Study endsJune 2029
Registry record updatedApril 29, 2026
Trial IDNCT07292649 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Pregnant women over 18 planning a vaginal delivery at the Padova center who can give informed consent and have no known major psychiatric history.

Probably not a fit

Women who have a planned or unplanned Cesarean delivery, have prior psychiatric diagnoses, contraindications to neuraxial analgesia, or language barriers are unlikely to benefit from or be eligible for this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll pregnant women over 18 planning vaginal delivery at the University Hospital of Padova who provide informed consent. Participants' expectations about labor analgesia will be recorded before delivery and the actual analgesia received (epidural, spinal, or none) will be documented. Researchers will follow participants after birth to compare the incidence of postpartum depression between those whose analgesia expectations were met versus unmet, excluding women with known psychiatric disorders or Caesarean delivery. The study aims to identify whether unmet expectations around labor pain management are associated with higher postpartum depression rates.

Why it matters

Potential benefit: If a link is found, the results could help clinicians better counsel and manage labor pain to reduce the risk of postpartum depression.

How similar studies have gone: Previous studies exploring labor pain, analgesia, and postpartum mood have produced mixed results, so this question is not yet settled.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Signed informed consent
* Planned vaginal delivery (spontaneous or induced)
* Pregnancy
* Age \> 18 years

Exclusion Criteria:

* Allergy to local anesthetics
* Language barrier
* Contraindications to labor analgesia
* Delivery by Cesarean section
* Known history of psychiatric disorders (including major depression)

Where it's running

  • University Hospital of Padova
    Padova, Veneto, Italy
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.