Methyl-Donor Rich Diet in the Postpartum Period

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial will enroll 100 postpartum women in Bursa, Türkiye, who have low intake of key methyl-donor nutrients. Participants will be randomly assigned to receive a two-month, individualized methyl-donor–rich diet and nutrition education or standard postpartum care. The study will compare maternal depressive symptoms, breastfeeding success, and infant weight between groups, with dietary intake monitored throughout. Eligibility emphasizes recent delivery, exclusive breastfeeding, and adequate health without psychiatric conditions or major comorbidities. The trial aims to determine if targeted nutrition can influence mood, feeding outcomes, and early infant growth.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18-40 years.
* Women presenting within the first 15 days after delivery.
* Mothers who had a term delivery (≥37 completed weeks of gestation).
* Mothers who are breastfeeding and whose infants are exclusively breastfed.
* No diagnosed psychiatric disorder or related medication use.
* No use of dietary supplements, including omega-3 supplements.
* No special diet program.
* No history of gestational diabetes, type 1 or type 2 diabetes, or insulin resistance.
* No malabsorption-related disorders, such as celiac disease or Crohn's disease.
* At least one assessed methyl donor nutrient intake below two-thirds of the applicable recommended intake, based on a 3-day dietary record.
* Willingness to participate voluntarily.

Exclusion Criteria:

* Development of serious postpartum complications, such as postpartum hemorrhage or sepsis.
* A maternal or infant health condition requiring prolonged hospitalization.
* Introduction of complementary foods to the infant during the study.
* Maternal smoking or alcohol use.
* Failure to adhere to the dietary intervention.
* Failure to attend follow-up assessments or voluntary withdrawal from the study.

Where it's running

• Orhaneli Merkez Aile Sağlığı Merkezi
  Bursa, Orhaneli̇, Turkey (Türkiye) Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.