Condition

Stage II Lip and Oral Cavity Cancer AJCC v8 clinical trials and research

• 4Clinical trials
• 2Countries

Newest Stage II Lip and Oral Cavity Cancer AJCC v8 clinical trials

All recruiting trials (4)

• Adding chemotherapy or chemo-immunotherapy to standard salvage surgery for advanced head and neck cancer

  This trial tests whether giving chemotherapy alone or chemotherapy plus the immunotherapy cemiplimab before salvage surgery helps people with PD-L1–positive recurrent or persistent head and neck squamous cell carcinoma.

  Recruiting at 114 sites Phase 2 National Cancer Institute (NCI) · Tucson, Arizona and 114 other locations · NCT07195734

• Personalized neck radiation guided by sentinel lymph node biopsy for oral cavity cancer

  This phase II trial sees if using sentinel lymph node biopsy to guide which side(s) of the neck get radiation can safely reduce unnecessary radiation for people with oral cavity squamous cell carcinoma.

  Recruiting Phase 2 University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07121595

• Adding BMX-001, a drug that protects normal tissue from radiation damage, to standard chemoradiation for head and neck cancer

  This trial tests whether giving BMX-001 along with usual mouth-care reduces severe mouth sores in people getting cisplatin-based chemoradiation for HPV-related and other head and neck cancers.

  Recruiting at 146 sites Phase 2 NRG Oncology · Gilbert, Arizona and 152 other locations · NCT06532279

• Sentinel lymph node biopsy versus standard neck dissection for early-stage oral cavity cancer

  This trial tests whether removing only the sentinel lymph nodes instead of doing a full neck dissection helps people with early-stage oral cavity cancer have better neck and shoulder function while keeping cancer control the same.

  Recruiting at 88 sites Phase 2/3 NRG Oncology · Birmingham, Alabama and 106 other locations · NCT04333537

Related topics

Quick answers

How many Stage II Lip and Oral Cavity Cancer AJCC v8 clinical trials are recruiting right now?

4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (4 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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