Condition

Noonan Syndrome clinical trials and research

• 10Clinical trials
• 1NIH research projects
• 2New in 30 days
• 6Countries

Newest Noonan Syndrome clinical trials

All recruiting trials (10)

• National Registry for Noonan Syndrome (Italy)

  This registry will collect genetic and clinical information from people with Noonan syndrome in Italy to understand how the condition changes over time and how treatments like growth hormone may work.

  Recruiting at 35 sites Istituto Giannina Gaslini · Ancona and 34 other locations · NCT07881159

• Neuroradiology Features in Noonan Syndrome and Gene-Linked Brain Differences

  This study tests brain MRI and MR angiography in people with Noonan syndrome to see how brain imaging patterns relate to their specific genetic mutations.

  Recruiting at 10 sites Istituto Giannina Gaslini · Bari and 9 other locations · NCT07881081

• Lipid and glucose patterns in Noonan syndrome and related RASopathies by age, sex, and genotype

  This project will see how lipid and glucose levels differ by age, sex, and genetic type in people with Noonan syndrome and related RASopathies.

  Recruiting at 3 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Alessandria and 13 other locations · NCT07464821

• Using advanced heart MRI to improve diagnosis and risk prediction for rare cardiomyopathies

  This project tests whether advanced cardiac MRI techniques can help diagnose and predict future risk for people with rare heart muscle diseases like Danon, Fabry, cardiac amyloidosis, Noonan syndrome, and cardiac sarcoidosis.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing · NCT07336394

• Using MEK inhibitors to treat hypertrophic cardiomyopathy in children with RASopathies

  This study is testing if a new medication called trametinib can help children with RASopathies and hypertrophic cardiomyopathy feel better compared to standard treatment alone.

  Recruiting Phase 2 Medical University of Warsaw · Warsaw · NCT06555237

• Therapy to help caregivers of children with genetic disorders manage stress

  This study tests whether a remote therapy program can help caregivers of children with genetic disorders manage their stress better.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05361811

• Collection of biological samples to study Noonan syndrome

  This study is collecting blood and urine samples from people with Noonan syndrome to help researchers learn more about the condition and how it affects patients.

  Recruiting University Hospital, Toulouse · Toulouse · NCT05202210

• Study of genetic and clinical aspects of RASopathies in children and adults

  This study is testing how genetic and clinical factors in people with RASopathies can help us understand their health risks and improve cancer screening for both children and adults.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT04888936

• Observing the health management of patients with rare genetic syndromes

  This study looks at how patients with rare genetic syndromes like Prader-Willi and Klinefelter manage their health as they move from children's care to adult care to see what support they need.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT04463316

• Collection of bio-specimens from patients with RASopathies

  This study is collecting samples from people with RASopathies to help researchers learn more about these rare genetic disorders and how they affect the body.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT04395495

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Brain development in Noonan syndrome: how brains grow from childhood to adolescence

  This project follows children and teens with Noonan syndrome to map how their brain grows and changes over time.

  NIH research Stanford University · Stanford, United States · NIH-11433381

Related topics

Quick answers

How many Noonan Syndrome clinical trials are recruiting right now?

10, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in Italy (3 trials), United States (3 trials), Netherlands (1 trial), France (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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