Brain development in Noonan syndrome: how brains grow from childhood to adolescence

Who could benefit from this research

What this research studies

We are studying kids and teens with Noonan syndrome to understand how their brain networks, structure, and connections develop during adolescence. Using advanced brain imaging, we will track changes in specific brain regions and white matter as they go through puberty. The goal is to link these brain changes with cognitive and behavioral outcomes so we can time future interventions. The study is anchored to the participants’ clinical care, hoping to identify windows when support could be most helpful. Results could point to personalized strategies to support learning and behavior in NS.

Why it matters

Where this research is happening

• Stanford University
  Stanford, United States Active

Researchers

• Principal investigator: Green, Tamar — Stanford University
• Study coordinator: Green, Tamar

Related research

Other NIH-funded projects on the same topics.

• National Registry for Noonan Syndrome (Italy)

  This registry will collect genetic and clinical information from people with Noonan syndrome in Italy to understand how the condition changes over time and how treatments like growth hormone may work.

  Recruiting at 35 sites Istituto Giannina Gaslini · Ancona and 34 other locations · NCT07881159

• Neuroradiology Features in Noonan Syndrome and Gene-Linked Brain Differences

  This study tests brain MRI and MR angiography in people with Noonan syndrome to see how brain imaging patterns relate to their specific genetic mutations.

  Recruiting at 10 sites Istituto Giannina Gaslini · Bari and 9 other locations · NCT07881081

• Lipid and glucose patterns in Noonan syndrome and related RASopathies by age, sex, and genotype

  This project will see how lipid and glucose levels differ by age, sex, and genetic type in people with Noonan syndrome and related RASopathies.

  Recruiting at 3 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Alessandria and 13 other locations · NCT07464821

• Using advanced heart MRI to improve diagnosis and risk prediction for rare cardiomyopathies

  This project tests whether advanced cardiac MRI techniques can help diagnose and predict future risk for people with rare heart muscle diseases like Danon, Fabry, cardiac amyloidosis, Noonan syndrome, and cardiac sarcoidosis.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing · NCT07336394

• Using MEK inhibitors to treat hypertrophic cardiomyopathy in children with RASopathies

  This study is testing if a new medication called trametinib can help children with RASopathies and hypertrophic cardiomyopathy feel better compared to standard treatment alone.

  Recruiting Phase 2 Medical University of Warsaw · Warsaw · NCT06555237

• Therapy to help caregivers of children with genetic disorders manage stress

  This study tests whether a remote therapy program can help caregivers of children with genetic disorders manage their stress better.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05361811

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.