Condition
NF1 clinical trials and research
As of November 12, 2026, Find a Trial lists 3 NF1 clinical trials that are recruiting, in United States. By phase: Phase 2 (1), Phase 1/2 (1), Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1Country
Newest NF1 clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Imlygic (T-VEC) injections for cutaneous neurofibromas in adults with NF1 | Phase 1 | Baltimore, Maryland | Recruiting | Aug 3, 2025 |
| Mirdametinib treatment for adults with Neurofibromatosis 1 and skin tumors | Phase 1/2 | Baltimore, Maryland | Recruiting | Dec 6, 2023 |
| Selumetinib plus ZEN-3694 with durvalumab for certain sarcomas and NF1-associated MPNST | Phase 2 | Birmingham, Alabama | Recruiting | Feb 23, 2022 |
All recruiting trials (3)
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Imlygic (T-VEC) injections for cutaneous neurofibromas in adults with NF1
This trial will test whether injecting Imlygic into bothersome cutaneous neurofibromas can shrink them or reduce symptoms in adults with NF1 who want local treatment.
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Mirdametinib treatment for adults with Neurofibromatosis 1 and skin tumors
This study is testing a new treatment called mirdametinib to see if it can help adults with Neurofibromatosis 1 and skin tumors feel better and manage their condition.
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Selumetinib plus ZEN-3694 with durvalumab for certain sarcomas and NF1-associated MPNST
This trial tests a combination of medicines to see if they can help adults with unresectable or metastatic sarcomas, including NF1-associated MPNST.
Related topics
Quick answers
How many NF1 clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.