Drug or treatment

Selumetinib clinical trials

• 9Clinical trials
• 1New in 30 days
• 5Countries

Newest trials

All recruiting trials (9)

• Real-world use of selumetinib for adult NF1 with inoperable plexiform neurofibromas

  This registry-following study tests how well and safely selumetinib works in adults with NF1 who have symptomatic, inoperable PN.

  Recruiting AstraZeneca · Beijing and 25 other locations · NCT07888517

• Combo therapy with selumetinib and trastuzumab deruxtecan for advanced pancreatic cancer

  This phase 1/2 trial tests whether the combination of selumetinib and DS-8201a (trastuzumab deruxtecan) is safe and whether it can help people with unresectable or metastatic pancreatic ductal adenocarcinoma.

  Recruiting Phase 1/2 National Cancer Institute (NCI) · Pittsburgh, Pennsylvania · NCT07619521

• MeK and MDM2 inhibitors in NF1-related tumors

  This study tests a combination of selumetinib and APG-115 in adults and older teens with NF1 who have unresectable or metastatic MPNST or related conditions to see if the treatment is tolerable and helps slow or stop tumor growth.

  Recruiting at 2 sites Phase 1/2 Children's National Research Institute · Washington D.C., District of Columbia and 1 other locations · NCT06735820

• Combination therapy to shrink plexiform neurofibromas in NF1 patients

  This trial tests whether the drugs cabozantinib and selumetinib can be safely given together to see if they help shrink progressive or painful plexiform neurofibromas in adolescents and adults with NF1.

  Recruiting at 8 sites Phase 1 University of Alabama at Birmingham · Birmingham, Alabama and 7 other locations · NCT06502171

• Study on the use of Koselugo for treating Neurofibromatosis 1

  This study is testing how well Koselugo works and how safe it is for people with Neurofibromatosis 1 in everyday treatment settings in South Korea.

  Recruiting at 9 sites AstraZeneca · Busan and 11 other locations · NCT06360406

• Early selumetinib to try to prevent plexiform neurofibromas in young children with NF1

  This trial will see if giving selumetinib to young children with NF1 who are at high risk can prevent or slow the development of plexiform neurofibromas.

  Recruiting at 15 sites Phase 2 University of Alabama at Birmingham · Birmingham, Alabama and 14 other locations · NCT06188741

• Selumetinib plus ZEN-3694 with durvalumab for certain sarcomas and NF1-associated MPNST

  This trial tests a combination of medicines to see if they can help adults with unresectable or metastatic sarcomas, including NF1-associated MPNST.

  Recruiting Phase 2 University of Alabama at Birmingham · Birmingham, Alabama · NCT05253131

• Comparing selumetinib to standard chemotherapy for low-grade glioma

  This study is testing if a new drug called selumetinib can help people with low-grade glioma live longer without their cancer getting worse compared to the usual chemotherapy.

  Recruiting at 124 sites Phase 3 National Cancer Institute (NCI) · Birmingham, Alabama and 131 other locations · NCT04166409

• Combining selumetinib and azacitidine for high-risk chronic blood cancers

  This study is testing a new combination of two drugs, selumetinib and azacitidine, to see if it can help people with high-risk chronic blood cancers like chronic myeloid leukemia and myelofibrosis.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT03326310

Quick answers

How many clinical trials of Selumetinib are recruiting right now?

9, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (7 trials), China (1 trial), Canada (1 trial), Puerto Rico (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 2, Phase 1/2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →