Drug or treatment

Mirdametinib clinical trials

• 10Clinical trials
• 3Countries

Newest trials

All recruiting trials (10)

• How probenecid affects mirdametnib in healthy adults

  This study tests how taking probenecid changes the way mirdametnib and its metabolites behave in the body of healthy adults.

  Recruiting Phase 1 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany · Neu-Ulm · NCT07840612

• Mirdametinib for people with central nervous system tumors

  This trial tests whether mirdametinib is safe and can help adults with central nervous system tumors, including glioma and neurohistiocytosis.

  Recruiting at 7 sites Phase 1/2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07539441

• Mirdametinib for advanced NF1‑mutant melanoma

  This study tests whether the MEK inhibitor mirdametinib can slow or stop disease in people with advanced NF1‑mutant melanoma whose cancer progressed after prior immunotherapy.

  Recruiting Phase 2 Sutter Health · San Francisco, California · NCT07237100

• Mirdametinib for relapsed or refractory chronic lymphocytic leukemia and small lymphocytic lymphoma

  This phase II trial tests whether the oral MEK inhibitor mirdametinib can shrink or control relapsed or treatment-resistant chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in adults.

  Recruiting at 9 sites Phase 2 National Cancer Institute (NCI) · Duarte, California and 8 other locations · NCT07061951

• Testing mirdametinib with palbociclib for treating liposarcoma

  This study is testing a new combination of two medications, mirdametinib and palbociclib, to see if they can help people with advanced liposarcoma feel better and improve their treatment options.

  Recruiting at 7 sites Phase 1/2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06843967

• Combining mirdametinib and vorinostat for treating specific nerve tumors in NF1 patients

  This study is testing a new combination of two medications to see if they can help patients with a specific type of nerve tumor related to Neurofibromatosis type 1 before starting regular treatments.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06693284

• Mirdametinib plus vinblastine for newly diagnosed pediatric low-grade glioma with MAPK activation

  This trial will test whether giving oral mirdametinib together with weekly vinblastine helps children and young adults (ages 2–25) with newly diagnosed low-grade glioma that shows MAPK pathway activation.

  Recruiting at 10 sites Phase 1/2 St. Justine's Hospital · Calgary, Alberta and 9 other locations · NCT06666348

• Mirdametinib treatment for adults with Neurofibromatosis 1 and skin tumors

  This study is testing a new treatment called mirdametinib to see if it can help adults with Neurofibromatosis 1 and skin tumors feel better and manage their condition.

  Recruiting Phase 1/2 Johns Hopkins University · Baltimore, Maryland · NCT06159166

• Treatment with mirdametinib for histiocytic disorders

  This study is testing a new treatment called mirdametinib to see if it helps people with Langerhans cell histiocytosis and other histiocytic disorders feel better with fewer side effects than current options.

  Recruiting Phase 2 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT06153173

• Evaluating mirdametinib for low-grade glioma in young patients

  This study is testing a new drug called mirdametinib to see if it can safely help young patients with low-grade glioma feel better and live longer.

  Recruiting Phase 1/2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04923126

Quick answers

How many clinical trials of Mirdametinib are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (8 trials), Canada (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 5, Phase 2: 3, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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