Pain testing for people with idiopathic REM sleep behavior disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will recruit people with polysomnography-confirmed idiopathic REM sleep behavior disorder and a control group of patients with narcolepsy type 1 who have coexisting REM sleep behavior disorder. Participants will complete standardized pain questionnaires and undergo quantitative thermal pain testing to measure pain thresholds and responses; motor symptom evaluations are not part of the protocol. The aim is to characterize pain perception in iRBD as a possible prodromal feature of Parkinson disease and to compare it with a control population. Results will inform whether pain measures could help identify early neurodegenerative changes or improve symptom management.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Diagnosed with iRBD confirmed by polysomnography;
* No clinical diagnosis of Parkinson's disease or other diagnosis of neurodegenerative disease;
* Ability to understand and complete study procedures and questionnaires;

Control group:

* Diagnosed with narcolepsy type 1;
* Coexisting REM sleep behavior disorder confirmed by polysomnography;
* Ability to understand and complete study procedures and questionnaires;

Exclusion Criteria:

* Diagnosed Parkinson's Disease, dementia with Lewy bodies or multiple system atrophy;
* Severe depression according to Diagnostic and Statistical Manual of Mental Disorders (DSM V);
* Inability to complete study procedures or questionnaires.

Where it's running

• Centre Expert Parkinson Hôpital Pierre Paul Riquet Place du Docteur Baylac
  Toulouse, France Recruiting

Study contacts

• Study coordinator: Christine BREFEL COURBON
• Email: christine.brefel-courbon@univ-tlse3.Fr
• Phone: 05 61 77 60 39

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns

  This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.

  Recruiting University of Cambridge · Cambridge, CB2 · NCT07786116

• Temporal interference stimulation for narcolepsy type 1

  A noninvasive brain stimulation test to see if theta-burst temporal interference can help people with narcolepsy type 1.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT07727239

• Long-term test of TAK-360 in people with narcolepsy or idiopathic hypersomnia

  This study tests TAK-360 over an extended period to see if it is tolerable for people with narcolepsy type 1, narcolepsy type 2, or idiopathic hypersomnia who completed an earlier TAK-360 trial.

  Recruiting at 33 sites Phase 2/3 Takeda · Chula Vista, California and 32 other locations · NCT07646678

• TAK-360 in adults with narcolepsy Type 1 with cataplexy

  This study tests TAK-360 versus placebo in adults with narcolepsy Type 1 to see if it is safe and tolerable.

  Recruiting at 9 sites Phase 2 Takeda · Redwood City, California and 17 other locations · NCT07633301

• Test of Cleminorexton vs placebo for central hypersomnolence in NT1/NT2

  This study tests cleminorexton to see if it helps daytime sleepiness in adults with Narcolepsy Type 1 or Type 2 compared with a placebo.

  Recruiting at 26 sites Phase 2/3 Centessa Pharmaceuticals plc · Birmingham, Alabama and 25 other locations · NCT07598708

• ALKS 2680 in adults with narcolepsy type 1: see if it helps daytime sleepiness and cataplexy

  This study tests whether ALKS 2680 helps reduce daytime sleepiness and cataplexy in adults with narcolepsy type 1 compared with a placebo.

  Recruiting at 20 sites Phase 3 Alkermes, Inc. · Brandon, Florida and 19 other locations · NCT07540897

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.