Condition

Malignant Ascites clinical trials and research

• 8Clinical trials
• 2Countries

Newest Malignant Ascites clinical trials

All recruiting trials (8)

• TLR9-based immunotherapy for peritoneal cancer with ascites

  This trial tests ACM-CpG injections into the abdomen to see if it’s safe and can help people with peritoneal metastases or malignant ascites from colorectal or appendiceal cancer.

  Recruiting Phase 1 Brown University · Providence, Rhode Island · NCT07658196

• Home paracentesis for cancer-related malignant ascites

  This study tests whether patients with cancer-related malignant ascites can safely and effectively have an ultrasound-guided paracentesis performed at home to relieve symptoms.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07490626

• Intraperitoneal liposomal irinotecan alone or with rmhTNF or bevacizumab for malignant ascites after prior treatments

  This will try an injected form of liposomal irinotecan, alone or with rmhTNF or bevacizumab, in adults with malignant ascites who have not responded to standard therapies.

  Recruiting Phase 1/2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07397819

• SIM0388 intraperitoneal treatment for malignant ascites

  This Phase I trial will test whether intraperitoneal Docetaxel polymeric micelles (SIM0388) can safely reduce malignant ascites in adults with advanced solid tumors who have exhausted or are not candidates for standard therapies.

  Recruiting Phase 1 Jiangsu Simcere Pharmaceutical Co., Ltd. · Shanghai, Shanghai Municipality · NCT07007988

• Combining Bevacizumab and Serplulimab with a New Treatment for Malignant Ascites

  This study is testing a new treatment that combines two drugs with a special therapy to see if it can help people with severe abdominal fluid buildup from digestive system cancers who haven't found relief from other treatments.

  Recruiting at 3 sites Phase 2 Sun Yat-sen University · Guangzhou, Guangdong and 2 other locations · NCT06433869

• Infusing tocilizumab into chest and abdominal cavities for advanced cancer patients

  This study is testing if giving tocilizumab directly into the chest and abdomen can help advanced cancer patients with fluid buildup feel better and respond to treatment.

  Recruiting Phase 1 Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT06016179

• Dual-targeting CAR-T therapy for advanced cancer patients with pleural or peritoneal metastases

  This study is testing a new type of CAR-T therapy that targets specific proteins in advanced cancer patients with tumors in the pleural or peritoneal cavities to see if it helps them when other treatments haven't worked.

  Recruiting Phase 1 Sichuan University · Chengdu, Sichuan · NCT05477927

• A halting of malignant ascites with apatinib in patients with cancer-related ascites

  This trial tests whether daily oral apatinib can help people with cancer-related malignant ascites who have not responded to other treatments.

  Recruiting Phase 2 The First Affiliated Hospital of Bengbu Medical University · Bengbu, Anhui · NCT03020979

Related topics

Quick answers

How many Malignant Ascites clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in China (5 trials), United States (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 4, Phase 2: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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