Condition

Lower Limb Amputation clinical trials and research

• 11Clinical trials
• 4NIH research projects
• 7Countries

Newest Lower Limb Amputation clinical trials

All recruiting trials (11)

• Cognitive Game-Based Exercise for Amputee Football Players

  This program tests if a cognitive game-based exercise plan can improve thinking and physical skills in amputee football players.

  Recruiting Tarsus University · Adana · NCT07840781

• Role of Visual Attention and Environment on Real-World Walking for People With Lower Limb Amputation

  This study tests how vision-based thinking and different walking environments affect real-world gait in people with a leg amputation.

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT07831707

• Dual-Task Balance Training for Traumatic Lower-Limb Prosthesis Users

  This trial tests whether adding dual-task balance training to standard rehab helps improve balance and mobility for adults with traumatic leg amputations who use a prosthesis.

  Recruiting Al-Azhar University - Gaza · Gaza, Gaza Strip · NCT07706452

• Footwear effects on walking in people with a leg prosthesis

  This study tests four different types of footwear to see how they affect walking in adults with a unilateral transtibial amputation who use a prosthetic foot.

  Recruiting University of Salford · Manchester, Greate Manchester · NCT07685496

• Motorized knee and ankle prostheses for people with above-knee amputations

  We will test whether a lightweight powered knee combined with different ankle setups and controllers can reduce effort and improve walking and stair mobility for people with a single above-knee amputation.

  Recruiting Early Phase 1 University of Utah · Salt Lake City, Utah · NCT07486063

• Using socket-induced phantom sensations to add walking feedback after lower-limb amputation

  This trial will test whether changing a prosthetic socket to create phantom limb sensations that line up with walking can help people with a lower-limb amputation walk more naturally.

  Recruiting Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est · Nancy · NCT07191795

• Exploratory test of walking, balance, and energy with new devices after leg amputation

  This study tests new CE-marked devices to see if they help people with lower leg or above-knee amputations walk and balance better without changing their usual care.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT07094074

• Multidisciplinary rehabilitation for patients with lower limb amputation

  This study is testing whether a new technology-based rehabilitation program can help people adjust better after having a lower limb amputation compared to traditional rehab methods.

  Recruiting Istituti Clinici Scientifici Maugeri SpA · Pavia, PV · NCT06471855

• Understanding what limits walking for people with a leg amputation

  This observational study in adults with lower limb amputation tests how various factors affect their ability to walk and rehab progress.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes, Gard · NCT06415955

• Using methylene blue to manage pain after lower limb amputation

  This study is testing if a combination of methylene blue and bupivacaine can help reduce pain after lower limb amputation and prevent long-term phantom pain for patients.

  Recruiting Tanta University · Tanta, Gharbia Governorate · NCT05830630

• Understanding how amputees navigate slopes and stairs with prostheses

  This study looks at how people with lower limb amputations use different types of prosthetic legs to walk up and down stairs and slopes to help improve future prosthetic designs.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT04030650

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted spinal-cord electrodes to restore feeling after lower-limb amputation

  This project is designing and testing thinner, more flexible spinal-cord electrodes to create focused sensations for people with lower-limb amputations.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11314502

• Improving walking for Veterans with non‑traumatic leg amputation

  A rehabilitation program aims to help Veterans with non‑traumatic lower‑limb amputation walk more evenly and reduce disability.

  NIH research VA Eastern Colorado Health Care System · Aurora, UNITED STATES · NIH-11249121

• Using electrodes to stimulate the spinal cord for restoring sensation in amputees

  This study is working on creating better electrodes that can help people with lower-limb amputations feel sensations in their missing leg, which could make it easier for them to balance and move around safely.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11046662

• Improving walking ability for veterans with non-traumatic lower limb amputation

  This study is looking to help veterans with non-traumatic lower limb amputations, like those caused by diabetes, walk more evenly and comfortably, so they can enjoy a better quality of life and avoid further health problems.

  NIH research VA Eastern Colorado Health Care System · Aurora, UNITED STATES · NIH-10988225

Related topics

Quick answers

How many Lower Limb Amputation clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in France (4 trials), United States (2 trials), Egypt (1 trial), Palestinian Territories (1 trial), Turkey (Türkiye) (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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