Using methylene blue to manage pain after lower limb amputation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of continuous perineural infusion of methylene blue combined with bupivacaine in reducing acute postoperative pain and preventing chronic phantom pain in patients undergoing lower limb amputation. It is a prospective randomized controlled trial that aims to address the challenging issue of post-amputation pain management. Methylene blue is known for its analgesic properties and ability to block pain transmission, making it a potential candidate for improving pain outcomes in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of both genders, suffering from vascular insufficiency of one or both lower limbs and scheduled for above or below knee amputation under general anesthesia.

Exclusion Criteria:

* Patients with a history of allergy to local anesthetics.
* Patients with allergy to methylene blue.
* Anticoagulant use or coagulopathy.

Where it's running

• Tanta University
  Tanta, Gharbia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Osama M Rehab, MD
• Email: osamarehab@med.tanta.edu.eg
• Phone: 00201095210806

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.