Understanding what limits walking for people with a leg amputation
Official title: Identification of Limiting Factors in the Locomotor Activity of Individuals With Lower Limb Amputation: Biomechanical, Physiological, Psychological.
Run by Centre Hospitalier Universitaire de Nīmes · NCT06415955 · Data updated 2026-11-12
This observational study in adults with lower limb amputation tests how various factors affect their ability to walk and rehab progress.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nīmes Academic / other |
| Locations | 1 site (Nîmes, Gard) |
| Status | Recruiting |
| Started | March 15, 2025 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | June 24, 2026 |
| Trial ID | NCT06415955 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with lower limb amputation receiving rehabilitation at CHU de Nîmes, who can walk at least 5 minutes on a treadmill and have appropriate, validated vascular equipment.
✕Probably not a fit
Patients who cannot walk 5 minutes on a treadmill, have uncorrected visual or major cognitive issues, or have conditions that prevent participation may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study observes adults with lower limb amputation to identify factors that influence return to walking and rehabilitation outcomes. It collects information on mobility, equipment fit, muscle mass maintenance, balance, and participation in daily activities. No interventions are applied; researchers analyze real-world data from routine rehabilitation settings at CHU de Nîmes. The goal is to identify key contributors to successful walking resumption after amputation. Findings could inform better rehabilitation strategies and equipment optimization.
Why it matters
Potential benefit: If successful, findings could help tailor rehabilitation plans to improve walking recovery and quality of life for amputees.
How similar studies have gone: Previous observational work has identified multiple factors influencing post-amputation rehabilitation, supporting this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Amputees in PRM hospitalisation at the CHU Nîmes RRL service University Rehabilitation Hospital in Le Grau du Roi. * All aetiologies: vascular, traumatic and septic. * Appropriate vascular equipment validated by PRM doctor. * Able to walk for 5 minutes on a treadmill. * Patient affiliated to or benefiting from a health insurance scheme. * Adult patient (\>18 years) and under 80 years of age. Exclusion Criteria: * Patients with uncorrected or untreated visual disorders. * Patients with major cognitive impairment (MOCA\>23). * Patients with vestibular disorders. * Patient with uncontrolled epilepsy. * Patient with an unhealed amputation stump. * Weight \> 135kg or \< 20kg * Patients with a FAC of 1 (i.e. patients requiring the firm and continuous assistance of another person to carry their weight and maintain their balance) or less. * Inability to properly adjust the sling to the corresponding body part due to: * Body shape * Colostomy bags * Skin lesions that cannot be adequately protected. * Any other reason that prevents the harness from being adjusted correctly and painlessly.
Where it's running
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CHU de Nîmes
Nîmes, Gard, France Recruiting
Study contacts
- Study coordinator: Eric PANTERA
- Email: eric.pantera@chu-nimes.fr
- Phone: +(33)4.66.68.25.36
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.