Condition

Stage III Rectal Cancer AJCC v8 clinical trials and research

• 9Clinical trials
• 2Countries

Newest Stage III Rectal Cancer AJCC v8 clinical trials

All recruiting trials (9)

• Zanidatamab given before surgery for HER2-positive colon or rectal cancer

  This tests whether giving zanidatamab before surgery helps adults with HER2-positive, RAS‑wildtype colon or rectal cancer who are planned for curative treatment.

  Recruiting at 4 sites Phase 2 Emory University · Atlanta, Georgia and 3 other locations · NCT07405476

• Family genetics: who shares test results with relatives

  This study tests whether letting patients share genetic results with their relatives is as good as doctors sharing the results to help first-degree relatives get genetic testing for hereditary cancer risk.

  Recruiting at 362 sites Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 364 other locations · NCT07143487

• Papaverine combined with radiation therapy for advanced rectal cancer

  This study is testing if adding papaverine to radiation therapy can help people with advanced rectal cancer feel better and improve their treatment results.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06834126

• Neoadjuvant FOLFOX with botensilimab and balstilimab for localized rectal cancer

  This test tries whether giving FOLFOX chemotherapy together with the immune drugs botensilimab and balstilimab before surgery helps people with localized rectal cancer achieve a complete clinical response.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT06780787

• Mobile health intervention to help colorectal cancer survivors and their caregivers follow lifestyle recommendations

  This study is testing a new mobile app to help colorectal cancer survivors and their caregivers stick to healthy lifestyle habits through goal-setting and coaching.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06746012

• Using blood tests to improve treatment strategies for rectal cancer

  This study is testing if measuring tumor DNA in the blood can help doctors see how well treatments are working for people with stage II-III rectal cancer.

  Recruiting at 2 sites OHSU Knight Cancer Institute · Portland, Oregon and 1 other locations · NCT05081024

• Short course radiation therapy combined with chemotherapy for stage II-III rectal cancer

  This study is testing a new treatment plan that combines short radiation therapy with chemotherapy to see if it helps people with stage II-III rectal cancer feel better and have fewer problems after treatment.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT04703101

• Monitoring and chemotherapy before surgery for stage II-III rectal cancer

  This study tests if monitoring and chemotherapy before surgery can help people with stage II-III rectal cancer keep their organs and improve their treatment choices.

  Recruiting Early Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03594630

• Evaluating quality of life after surgery for rectal cancer

  This study looks at how surgery for rectal cancer affects the quality of life for patients over time, comparing those who received radiation therapy to those who didn’t.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT02107105

Related topics

Quick answers

How many Stage III Rectal Cancer AJCC v8 clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (9 trials), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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