Short-course radiotherapy with Fruquintinib and Adebrelimab for advanced rectal cancer

Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study (UNION PRECISION-I)

This study is testing a new treatment plan that combines short radiation therapy with Fruquintinib and Adebrelimab for people with advanced rectal cancer to see if it helps them better than current methods.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 45 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (other)
• Drugs / interventions: chemotherapy, immunotherapy, prednisone, adebrelimab, fruquintinib, adbelimumab, fuquinitinib
• Locations: 1 site (Wuhan)
• Trial ID: NCT06234007 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the efficacy and safety of a treatment regimen combining short-course radiotherapy with Fruquintinib, Adebrelimab, and CAPOX in patients with locally advanced rectal cancer. The study follows a multicenter, single-arm, open-label design, where participants undergo a screening period, a treatment period involving neoadjuvant therapy, and a follow-up period for safety and survival assessments. The treatment includes a total of six cycles of Fruquintinib and CAPOX, followed by surgical resection after a brief rest period. Continuous safety evaluations are conducted throughout the study to ensure participant well-being.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18-75 with locally advanced rectal adenocarcinoma and specific high-risk features identified through pelvic MRI.

Not a fit: Patients who have previously received any anti-tumor treatment for rectal cancer or have surgical contraindications may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment approach could improve outcomes for patients with locally advanced rectal cancer by enhancing tumor response before surgery.

How similar studies have performed: Other studies have explored similar neoadjuvant approaches, but the specific combination of treatments in this trial is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Signed written informed consent and volunteered to participate in the study;
2. Age 18-75 years old (including the cut-off value), male or female;
3. Locally advanced rectal adenocarcinoma confirmed by histopathology;
4. High risk on pelvic MRI \[one of the following criteria\] :

   * Clinical tumor (cT) stage cT4a or cT4b (according to the AJCC, 8th edition)
   * Extramural vascular infiltration
   * Clinical lymph node (cN) stage cN2 (according to the AJCC, 8th edition)
   * Involvement of the mesenteric fascia
   * Enlarged lateral lymph nodes
5. The distance between the lower edge of the tumor and the anal edge is ≤10cm;
6. Able to swallow tablets and capsules normally;
7. ECOG PS 0-1
8. Have not received any anti-tumor treatment for rectal cancer, including surgery, radiotherapy, chemotherapy, targeted therapy, immunotherapy, etc.
9. Plan to undergo surgery after completion of total neoadjuvant therapy;
10. No surgical contraindications;
11. Normal major organ function, including:

    1. Routine blood test (no blood transfusion and blood products within 14 days prior to the first treatment, no correction with G-CSF and other hematopoietic stimulating factors) :

       * Neutrophil count ≥ 1.5×109/L
       * Platelet count ≥ 100×109/L
       * Hemoglobin ≥ 90 g/L
       * White blood cell count ≥ 3.0×109/L
    2. Blood biochemical tests:

       * Total bilirubin ≤ 1.5×ULN (Gilbert's syndrome subjects, ≤3×ULN; Tumor liver metastasis, total bilirubin ≤3×ULN)
       * ALT ≤ 2.5×ULN, AST ≤ 2.5×ULN (≤5×ULN for patients with liver metastases)
       * Serum creatinine ≤ 1.5×ULN, or creatinine clearance ≥ 50 mL/min (Cocheroft-Gault formula, see Annex 2)
    3. Coagulation function:

       * International Normalized ratio (INR) ≤ 1.5×ULN
       * Activated partial thromboplastin time (APTT) ≤ 1.5×ULN
       * Prothrombin time (PT) ≤1.5×ULN
    4. Doppler ultrasound assessment: left ventricular ejection fraction (LVEF)≥50%
12. Female subjects of childbearing potential were required to have a negative serum pregnancy test within 14 days before starting the trial drug and to have used an effective contraceptive method (e.g., an intrauterine device, contraceptive pill, or condom) during the trial and for at least 6 months after the last dose; Male participants whose partner is a woman of childbearing potential should use effective contraception during the trial and for 6 months after the last dose;

Exclusion Criteria:

1. Previous allergic history to any anti-angiogenesis targeted drug, any component of monoclonal antibody, capecitabine, oxaliplatin, or other platinum drugs;
2. Have received or are receiving any of the following:

   * being treated with an immunosuppressive drug, or systemic hormone, for immunosuppression within 2 weeks before the first dose of the study drug (dose\> 10mg/ day prednisone or equivalent); Inhaled or topical steroid use and dosage are allowed in the absence of active autoimmune disease; Prednisone 10mg/ day or equivalent dose of adrenocortical hormone replacement;
   * received live attenuated vaccine within 4 weeks before the first dose of study drug;
   * major surgery or severe trauma within 4 weeks before the first dose of study drug;
3. Have any active autoimmune disease or history of autoimmune disease, including but not limited to: interstitial pneumonia, enteritis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism (may be considered after hormone replacement therapy); Patients with psoriasis or complete remission of childhood asthma/allergies without any intervention in adulthood were considered for inclusion, but patients requiring medical intervention with bronchodilators were not included.
4. A history of immunodeficiency, including HIV positive, other acquired or congenital immunodeficiency diseases, or organ transplantation or allogeneic bone marrow transplantation;
5. The presence of uncontrolled cardiac symptoms or diseases, including but not limited to: (1) heart failure above NYHA class II, (2) unstable angina, (3) myocardial infarction within 1 year, (4) clinically significant supraventricular or ventricular arrhythmias without or poorly controlled after clinical intervention; (5) patients with hypertension that is not well controlled with a single antihypertensive drug (systolic blood pressure ≥150 mmHg, diastolic blood pressure ≥100mmHg), or patients using two or more antihypertensive drugs to control blood pressure; (6) New York Heart Association (NYHA) functional class \&gt; Grade II or left ventricular ejection fraction (LVEF) \< 50%;
6. Severe infection (CTCAE \> 2) occurred within 4 weeks before the first dose of study drug, such as severe pneumonia requiring hospitalization, bacteremia, and infectious complications; Prophylactic antibiotics were excluded if there was active pulmonary inflammation on baseline chest imaging, if there were signs and symptoms of infection within 14 days before the first dose of study drug, or if oral or intravenous antibiotics were required;
7. Patients with active pulmonary tuberculosis infection detected by medical history or CT examination, or with a history of active pulmonary tuberculosis infection within 1 year before enrollment, or with a history of active pulmonary tuberculosis infection more than 1 year before enrollment but without regular treatment;
8. Presence of active hepatitis B (HBV DNA ≥ 2000 IU/mL or 104 copies/mL), hepatitis C (hepatitis C antibody positive, and HCV RNA above the detection limit of the analytical method);
9. The patient had a second primary malignancy;
10. Pregnant or lactating women;
11. History of arterial/venous thrombosis events within 6 months, such as cerebrovascular accident (including transient ischemic attack), deep vein thrombosis and pulmonary embolism;
12. Persons with a history of psychotropic drug abuse and inability to quit or with mental disorders;
13. Patients with any constitutional sign or history of bleeding regardless of severity;
14. Patients with high risk of bleeding, such as active bleeding or bleeding tendency;
15. Urine routine test showed urine protein ≥++, and confirmed 24-hour urine protein quantitation \> 1.0 g;
16. According to the investigator's judgment, there are other factors that may lead to the forced termination of the study, such as other serious diseases (including mental diseases) requiring combined treatment, alcohol abuse, drug abuse, family or social factors, and factors that may affect the safety or compliance of the subjects.

Where this trial is running

Wuhan

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, China (RECRUITING)

Study contacts

• Principal investigator: Tao Zhang, Ph.D — Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
• Study coordinator: zhenyu Lin, Ph.D

Conditions: Locally Advanced Rectal Cancer, Neoadjuvant, Fruquintinib, Colorectal cancer