Condition

Irritability clinical trials and research

• 10Clinical trials
• 5NIH research projects
• 5Countries

Newest Irritability clinical trials

All recruiting trials (10)

• Grappling with Trauma: BJJ for First Responders

  This program tests whether eight weeks of Brazilian Jiu-Jitsu can be tied to changes in trauma-related symptoms for first responders who prefer movement-based activities over traditional mental health services.

  Recruiting Sam Houston State University · Conroe, Texas · NCT07783516

• Therapy approaches for irritability in youths: active treatments vs nonactive psychoeducation

  This study tests whether active psychotherapies for irritability in kids aged 8–16.5 years work better than nonactive, time-matched psychoeducation for children and their parents.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07640802

• Behavioral parent training with optional AI support for children with disruptive behaviors

  This trial will test whether adding a 24/7 AI assistant to online group behavioral parent training helps parents manage children aged 5–12 with disruptive behaviors.

  Recruiting Fundació Sant Joan de Déu · Barcelona, Barcelona · NCT07469215

• Fluoxetine's effect on anger-related emotional responses in young adults

  This study will test whether taking fluoxetine for one week changes how healthy 18–24-year-olds react to anger-related words, faces, memories, and frustrating tasks compared with a placebo.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07424781

• What predicts improvement in irritability and aggression in children with ADHD on stimulant medication

  This study sees if optimizing stimulant medication helps children with ADHD who have high irritability and aggression and whether brain and learning tests can predict who improves.

  Recruiting Phase 4 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06871488

• Using a new pathway to manage unexplained pain in children with severe neurological impairments

  This study is testing a new way for doctors to help manage unexplained pain in children with severe neurological impairments who can't tell us how they feel.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06869928

• Evaluating gene expression changes in children on antipsychotic medications

  This study is trying to see how antipsychotic medications affect the genes of children and teens with metabolic disorders, compared to those who don't take these medications, to find early signs of possible health issues.

  Recruiting IRCCS Eugenio Medea · Bosisio Parini, LC · NCT06814314

• Understanding how the brain reacts to frustration in healthy adults

  This study is trying to see how the brains of healthy adults react to frustration by using special tasks and brain imaging techniques.

  Recruiting Early Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT06484088

• Personalized brain stimulation for long-term symptoms after concussion

  This study will try personalized, noninvasive brain stimulation (TMS) to reduce dizziness, headaches, memory problems, and other lasting symptoms in adults aged 18–65 after a concussion.

  Recruiting Phase 2 University of California, Los Angeles · Westwood, Los Angeles, California · NCT06073886

• Psychological treatments for children with severe irritability

  This study is testing two types of therapy to see if they can help kids and teens with severe irritability feel better.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02531893

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Neural markers that predict how kids with ADHD respond to CNS stimulants

  This project looks at brain signals to see if they can predict which children with ADHD and aggression will benefit from stimulant medications.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11370254

• Understanding the brain mechanisms behind irritability in adolescents

  This study is looking at how feelings of irritability, or getting really angry when things don’t go as expected, develop in kids as they grow into teenagers, and it aims to find ways to help them manage these feelings early on to prevent bigger mental health problems later.

  NIH research San Diego State University · San Diego, United States · NIH-11001466

• Understanding and predicting irritability in children and adolescents

  This study is looking into what causes long-lasting irritability in kids and teens, helping us understand which young people might struggle with it so we can find better ways to support them.

  NIH research Yale University · New Haven, United States · NIH-10909435

• Understanding brain circuits related to irritability to find new treatments

  This study is looking at how certain brain connections affect irritability, especially in people with depression, to help create better treatments that can really make a difference for those who struggle with these feelings.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10908393

• Understanding how brain mechanisms affect irritability in young children

  This study looks at how young children, ages 3 to 6, react when they don’t get what they expect, to understand why some kids stay irritable while others grow out of it, which could help us find ways to support those who might struggle with their feelings as they get older.

  NIH research San Diego State University · San Diego, United States · NIH-10897811

Related topics

Quick answers

How many Irritability clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (6 trials), Spain (1 trial), Canada (1 trial), Italy (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 2: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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