Understanding and predicting irritability in children and adolescents

Multi-level mechanisms and predictors of irritability: An innovative approach bridging laboratory and real-world measures

NIH-funded research Yale University · NIH-10909435

This study is looking into what causes long-lasting irritability in kids and teens, helping us understand which young people might struggle with it so we can find better ways to support them.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionYale University NIH-funded
Lab location1 site (New Haven, United States)
Project IDNIH-10909435 on NIH RePORTER

What this research studies

This research investigates the causes and predictors of chronic irritability in children and adolescents, which can lead to significant emotional and behavioral issues. By examining various factors such as brain function, physiological responses, and social environments, the study aims to identify which young individuals are at risk for persistent irritability. The approach combines laboratory assessments with real-world data to create a comprehensive understanding of irritability's development. This innovative methodology seeks to fill the gap in effective treatments for chronic irritability.

Who could benefit from this research

Good fit: Ideal candidates for this research are children and adolescents aged 0-20 who exhibit signs of chronic irritability.

Not a fit: Patients who do not experience irritability or have other unrelated psychiatric conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better identification and treatment strategies for children and adolescents suffering from chronic irritability.

How similar studies have performed: While there has been some research on irritability, this approach is innovative and aims to address gaps in understanding chronic irritability, making it a novel investigation.

Where this research is happening

New Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.