Understanding brain circuits related to irritability to find new treatments
Official title: Elucidating the Neurocircuitry of Irritability with Ultra-High-Field Neuroimaging to Identify Novel Therapeutic Targets
Funded at Ut Southwestern Medical Center · NIH-10908393 · Data updated 2026-11-12
This study is looking at how certain brain connections affect irritability, especially in people with depression, to help create better treatments that can really make a difference for those who struggle with these feelings.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $183,081 |
| NIH project number | 5K23MH126202-04 |
| Project ID | NIH-10908393 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include adults experiencing irritability associated with depression or related mood disorders.
✕Less likely to help
Patients with irritability not linked to mood disorders or those outside the age range of 21+ years may not benefit from this research.
What this research studies
This research investigates the brain circuits involved in irritability using advanced imaging techniques. By employing ultra-high-field functional MRI, the study aims to identify specific neurocircuit mechanisms that contribute to irritability, particularly in individuals with depression. The findings could lead to the development of targeted antidepressant treatments that address these neurocircuit dysfunctions. Patients may participate in clinical trials that assess the effectiveness of these new therapies based on changes in brain function.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for irritability and related mood disorders, improving patients' quality of life.
How similar studies have gone: Previous research has shown promise in using neuroimaging to understand mood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Jha, Manish Kumar — Ut Southwestern Medical Center
- Study coordinator: Jha, Manish Kumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.