Condition

Refractory Non-Hodgkin Lymphoma clinical trials and research

• 15Clinical trials
• 5Countries

Newest Refractory Non-Hodgkin Lymphoma clinical trials

All recruiting trials (15)

• Ronde-cel versus standard CD19 CAR T‑cell therapy for relapsed or refractory large B‑cell lymphoma

  This test sees if ronde-cel, a CAR T therapy that targets both CD19 and CD20, works better than currently used CD19 CAR T therapies for adults whose large B‑cell lymphoma returned or did not respond after first‑line treatment.

  Recruiting at 41 sites Phase 3 Lyell Immunopharma, Inc. · Gilbert, Arizona and 43 other locations · NCT07188558

• Preventing CAR-T cell toxicities with emapalumab

  This study is testing if a drug called emapalumab can help prevent side effects in people with large B-cell non-Hodgkin's lymphoma who are receiving another treatment called axicabtagene ciloleucel.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT06550141

• Treatment for relapsed or refractory B-cell lymphoma using SynKIR-310

  This study is testing a new treatment called SynKIR-310 to see if it can help adults with relapsed or refractory B-cell lymphoma feel better.

  Recruiting at 5 sites Phase 1 Verismo Therapeutics · Denver, Colorado and 4 other locations · NCT06544265

• Combination treatment of pembrolizumab and ATRA for relapsed Hodgkin and Non-Hodgkin lymphoma

  This study is testing if a combination of two treatments, pembrolizumab and ATRA, can help adults with relapsed Hodgkin and Non-Hodgkin lymphoma feel better and improve their health.

  Recruiting at 2 sites Phase 2 Indiana University · Indianapolis, Indiana and 1 other locations · NCT06484920

• T-Cell Therapy for Adults with Relapsed B-Cell Non-Hodgkin's Lymphoma

  This study is testing a new T-cell therapy to see if it can help adults with relapsed B-cell non-Hodgkin's lymphoma feel better.

  Recruiting at 5 sites Phase 1/2 Estrella Immunopharma, Inc. · Sacramento, California and 4 other locations · NCT06343311

• IDP-023 treatment for advanced blood cancers

  This study is testing a new treatment called IDP-023, which uses special immune cells alone and with other medications to see if it can help people with advanced blood cancers like multiple myeloma and non-Hodgkin lymphoma.

  Recruiting at 9 sites Phase 1/2 Indapta Therapeutics, INC. · Los Angeles, California and 11 other locations · NCT06119685

• Using CD79b-19 CAR T cells to treat Non-Hodgkin Lymphoma

  This study is testing a new treatment using modified immune cells to see if it can help people with relapsed or hard-to-treat Non-Hodgkin Lymphoma.

  Recruiting Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT06026319

• Testing SIRPant-M for patients with relapsed or refractory Non-Hodgkin's lymphoma

  This study is testing a new cell therapy called SIRPant-M to see if it can help people with relapsed or hard-to-treat Non-Hodgkin's lymphoma feel better.

  Recruiting at 3 sites Phase 1 SIRPant Immunotherapeutics, Inc. · Duarte, California and 2 other locations · NCT05967416

• Testing HCB101 for advanced solid tumors and lymphoma

  This study is testing a new treatment called HCB101 to see if it can help adults with advanced solid tumors or certain types of lymphoma that haven't responded to other therapies.

  Recruiting at 8 sites Phase 1 FBD Biologics Limited · Port Saint Lucie, Florida and 7 other locations · NCT05892718

• Treatment of aggressive large B-cell lymphoma with LYL314

  This study is testing a new CAR T-cell therapy called LYL314 to see if it can effectively treat aggressive large B-cell lymphoma in different groups of patients.

  Recruiting at 35 sites Phase 1/2 Lyell Immunopharma, Inc. · Irvine, California and 34 other locations · NCT05826535

• Genetically engineered CAR T-cells for treating certain blood cancers

  This study is testing a new type of treatment using specially modified immune cells to see if they can help people with certain blood cancers that haven't responded to other treatments.

  Recruiting at 2 sites Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio and 1 other locations · NCT05418088

• Combination treatment for aggressive Non-Hodgkin's Lymphoma

  This study is testing a new combination of treatments for people with aggressive Non-Hodgkin's Lymphoma to see if it can help shrink their tumors when other treatments haven't worked.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT05260957

• CAR-T therapy for HIV-related aggressive B-cell lymphoma

  This study is testing a new CAR-T therapy to see if it can safely help people with HIV-related aggressive B-cell lymphoma that hasn't responded to other treatments.

  Recruiting at 7 sites Phase 1 AIDS Malignancy Consortium · Duarte, California and 6 other locations · NCT05077527

• Tegavivint treatment for recurrent or refractory solid tumors in children

  This study tests if a new intravenous medication called tegavivint can help children with tough-to-treat solid tumors, like Ewing sarcoma and desmoid tumors, by finding the right dose and seeing how well it works.

  Recruiting at 19 sites Phase 1/2 Children's Oncology Group · Birmingham, Alabama and 20 other locations · NCT04851119

• Using modified T cells to treat relapsed or refractory Non-Hodgkin Lymphoma

  This study is testing a new treatment using modified T cells to see if it can help people with relapsed or hard-to-treat Non-Hodgkin Lymphoma.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT04545762

Related topics

Quick answers

How many Refractory Non-Hodgkin Lymphoma clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (15 trials), Australia (2 trials), China (1 trial), Taiwan (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 7, Phase 1/2: 4, Phase 2: 3, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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