Investigating how cholecystokinin receptors affect liver cancer
Official title: Role of cholecystokinin receptor in hepatocellular cancer
Funded at Georgetown University · NIH-10898070 · Data updated 2026-11-12
This study is looking at how certain receptors in the body can affect liver cancer growth and spread, and it aims to find new ways to treat this type of cancer that could help patients in the future.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $162,969 |
| NIH project number | 5K01CA255572-04 |
| Project ID | NIH-10898070 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hepatocellular cancer or those at high risk due to conditions like nonalcoholic steatohepatitis.
✕Less likely to help
Patients with cancers unrelated to liver or gastrointestinal systems may not receive any benefit from this research.
What this research studies
This research focuses on the role of cholecystokinin (CCK) receptors in liver cancer, particularly how their activation can promote cancer growth and metastasis. The study will utilize advanced techniques, including CRISPR technology, to explore the mechanisms by which these receptors contribute to liver inflammation and fibrosis. By examining the interaction between CCK receptors and other cellular pathways, the research aims to uncover potential therapeutic targets for treating hepatocellular cancer. Patients may benefit from insights gained that could lead to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively target liver cancer and improve patient outcomes.
How similar studies have gone: Previous research has shown promising results in targeting CCK receptors in cancer models, indicating potential for success in this approach.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Gay, Martha — Georgetown University
- Study coordinator: Gay, Martha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.