Condition
ER-Positive HER2-Negative Breast Cancer clinical trials and research
As of November 12, 2026, Find a Trial lists 4 ER-Positive HER2-Negative Breast Cancer clinical trials that are recruiting, at sites in 10 countries (most in United States (3), South Korea (2), Canada (2)). By phase: Phase 2 (2), Phase 3 (1), Phase 1/2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 10Countries
Newest ER-Positive HER2-Negative Breast Cancer clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Camizestrant plus ribociclib in ER-positive, HER2-negative advanced breast cancer | Phase 3 | Duarte, California and 88 other locations | Recruiting | Jun 15, 2026 |
| Capecitabine for MRD-positive, resected ER+/HER2-negative breast cancer | Phase 2 | Toronto, Ontario | Recruiting | Jun 5, 2026 |
| Treatment for advanced breast cancer using RYZ101 | Phase 1/2 | Phoenix, Arizona and 30 other locations | Recruiting | Sep 19, 2024 |
| Chemotherapy with or without Tocilizumab for certain types of breast cancer | Phase 2 | Atlanta, Georgia and 6 other locations | Recruiting | May 6, 2023 |
All recruiting trials (4)
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Camizestrant plus ribociclib in ER-positive, HER2-negative advanced breast cancer
This trial tests whether camizestrant plus ribociclib can help people with ER-positive, HER2-negative metastatic breast cancer who have not yet had systemic therapy for advanced disease.
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Capecitabine for MRD-positive, resected ER+/HER2-negative breast cancer
This Phase 2 trial tests whether taking capecitabine can help people with resected, ER-positive/HER2-negative breast cancer who still have molecular residual disease after standard therapy.
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Treatment for advanced breast cancer using RYZ101
This study is testing a new treatment called RYZ101 for people with advanced breast cancer that can't be removed by surgery to see if it helps manage their condition.
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Chemotherapy with or without Tocilizumab for certain types of breast cancer
This study is testing if adding a drug called tocilizumab to standard chemotherapy helps people with certain types of advanced breast cancer feel better compared to just chemotherapy alone.
Related topics
Quick answers
How many ER-Positive HER2-Negative Breast Cancer clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 10 countries. The most sites are in United States (3 trials), South Korea (2 trials), Canada (2 trials), France (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 2, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.