Vascular Health in Adults with Down Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines endothelial function and arterial stiffness in adults with Down syndrome (18–35 years) and compares them to adults without Down syndrome to understand vascular aging. Participants will be generally healthy but sedentary, with specific inclusion and exclusion criteria to isolate cardiovascular risk factors. The study aims to identify how Down syndrome may influence age-related vascular changes and to measure markers that relate to cardiovascular and brain health. Details on specific measures and protocols are not provided in the available information.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* between 18 and 35 years old
* generally healthy
* sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day)

Additionally, for the participants with Down syndrome:

* diagnosis of Down syndrome trisomy 21
* normal thyroid function or stable thyroid function (and medications) for at least 6 months.

Exclusion Criteria:

* unresolved congenital heart disease;
* atherosclerotic or other vascular disease (such as blood clot history or clotting disorders);
* asthma or other pulmonary disease;
* hypertension (defined as BP \>140/90 mmHg); blood pressure below 90/60 mmHg;
* history of pre-syncope or syncope;
* diabetes (defined as glycated hemoglobin (HbA1c) of \>7.5% or use of glucose-lowering medication);
* severe obesity (defined as body mass index (BMI) \>40);
* heart medications affecting heart rate, blood pressure, or arterial function, including blood thinners; anti-inflammatory medication, including Nonsteroidal anti-inflammatory drugs (NSAIDS);
* current smoking;
* currently pregnant or planning to become pregnant during the study period;
* currently breastfeeding;
* unable or unwilling to use an acceptable method of contraception during the study timeframe;
* positive pregnancy test at screening.

Where it's running

• University of Nevada Las Vegas - UNLV
  Las Vegas, Nevada, United States Recruiting

Study contacts

• Study coordinator: Thessa Hilgenkamp, PhD
• Email: thessa.hilgenkamp@unlv.edu
• Phone: (702) 8951055

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.