Clinical trial Recruiting at 1 site Interventional Ages 12 to 18

Improving sleep to help adolescents with depression

Official title: A Confirmatory Efficacy Trial of Engaging a Novel Sleep/Circadian Rhythm Target as Treatment for Depression in Adolescents

Run by Children's Hospital Los Angeles · NCT06139861 · Data updated 2026-11-12

This study is testing if a new sleep program can help teenagers with depression feel better by improving their sleep schedule.

Quick facts

Study typeInterventional
Ages12 Years to 18 Years
SexAll
Enrollment200 (estimated)
SponsorChildren's Hospital Los Angeles
Academic / other
Locations1 site (Los Angeles, California)
StatusRecruiting
StartedMarch 15, 2024
Main results expectedAugust 1, 2028
Study endsAugust 1, 2028
Registry record updatedMay 11, 2026
Trial IDNCT06139861 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adolescents diagnosed with depression who also experience a misalignment between their biological circadian timing and waketime.

Probably not a fit

Patients with severe mental health conditions such as active psychosis or bipolar disorder, or those currently using medications that affect sleep, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to test whether enhancing the alignment between biological circadian timing and waketime can lead to better depression outcomes in adolescents suffering from depression and delayed sleep phase. It employs a cognitive-behavioral sleep intervention called TranS-C, along with psychoeducation, to address these issues. The trial is designed to be sufficiently powered to confirm the efficacy of this approach in a targeted adolescent population.

Why it matters

Potential benefit: If successful, this intervention could significantly improve the mental health and quality of life for adolescents struggling with depression and sleep issues.

How similar studies have gone: Other studies have shown promise in using cognitive-behavioral interventions to improve sleep and mental health outcomes, suggesting this approach may be effective.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Exclusion Criteria:

* mental health/behavioral symptoms that would preclude productive engagement in study assessments or intervention (e.g., active psychosis; Bipolar Disorder; drug dependence
* severe or unstable medical or psychiatric condition such that treatment has changed within the last month or is expected to change during the course of the study or that would preclude ability to adhere to study procedures (e.g. terminal end-stage cancer)
* current use of medications or herbs with known effects on sleep
* plan to undergo or have had medication change in the last 8 weeks

Where it's running

  • Children's Hospital Los Angeles
    Los Angeles, California, United States
    Recruiting

Study contacts

  • Principal investigator: Lauren M Asarnow, PhD — Children's Hospital Los Angeles
  • Study coordinator: Lauren Asarnow, PhD
  • Email: lasarnow@chla.usc.edu
  • Phone: 323-361-2471

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.