Condition

Congenital Heart Disease (CHD) clinical trials and research

• 17Clinical trials
• 1NIH research projects
• 8Countries

Newest Congenital Heart Disease (CHD) clinical trials

All recruiting trials (17)

• Improving transition of congenital heart disease care from pediatric to adult services

  This program will try a multi-step transfer process to reduce health declines in people with congenital heart disease who are waiting to see an adult specialist.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT07585175

• HeartGPS: Prenatal mental health support for mothers of babies with CHD

  A pregnant person or mother of a baby with congenital heart disease will try a virtual mental health program (HeartGPS) in addition to standard care to see if it helps with well‑being and infant development.

  Recruiting at 5 sites Carelon Research · Phoenix, Arizona and 16 other locations · NCT07582861

• Direct breastfeeding to support babies with congenital heart disease and their families

  This study tests a breastfeeding-focused program to help infants with CHD breastfeed directly and see how it affects infant health and parental well-being.

  Recruiting at 5 sites Carelon Research · Phoenix, Arizona and 16 other locations · NCT07582848

• Music and Multisensory Interventions for Pain During Chest Tube Removal in Infants with Congenital Heart Disease

  This trial tests whether music or a multisensory mobile intervention can reduce pain and stabilize physiology during chest tube removal in 2- to 12-month-old infants with congenital heart disease.

  Recruiting Baskent University · Ankara · NCT07564882

• MedlyPeds: a smartphone app to monitor kids with heart disease

  This study tests whether the MedlyPeds app can help kids with heart conditions and their families stay informed and track symptoms remotely.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT07556185

• Fontan outcomes with low versus high lung blood flow in single‑ventricle hearts

  This project will test whether people with single‑ventricle congenital heart disease who have reduced versus increased pulmonary blood flow do better or worse after the Fontan operation.

  Recruiting National Cardiovascular Center Harapan Kita Hospital Indonesia · Jakarta, DKI Jakarta · NCT07535203

• Coughing exercises versus incentive spirometry for breathing recovery after pediatric heart surgery

  This study will test whether coughing exercises or incentive spirometry help children aged 6–18 recover their breathing and lung function after heart surgery.

  Recruiting at 4 sites University of Baghdad · Baghdad, Baghdad Governorate and 3 other locations · NCT07405333

• AI prediction of complications after transcatheter closure of perimembranous VSD in children

  This project will try an AI model that combines clinical data, text notes, and images to predict which children undergoing transcatheter closure of perimembranous VSD are at higher risk of treatment-related complications.

  Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07375602

• Lifeline ductus arteriosus stent for infants with ductal-dependent circulation

  The trial will test whether the Lifeline ductus arteriosus stent safely keeps the ductus arteriosus open in infants under 6 months who need ductal-dependent pulmonary blood flow.

  Recruiting at 10 sites Starlight Cardiovascular Inc · Los Angeles, California and 10 other locations · NCT07114718

• Creating a network for children with congenital heart disease in China

  This study is setting up a network of hospitals in China to share information about children with congenital heart disease to improve research and care for these kids.

  Recruiting at 6 sites Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Wuhan, Hubei and 5 other locations · NCT06885307

• Butyric acid before heart surgery in infants and young kids with CHD

  This study tests whether giving butyric acid to infants and children aged 1 month to 3 years before heart surgery is safe and whether it improves gut health and lowers inflammation.

  Recruiting Phase 1/2 University of Nebraska · Omaha, Nebraska · NCT06882772

• Pre-surgery sleep program to reduce delirium after congenital heart surgery in infants and toddlers

  This study will try a short cognitive-behavioral sleep program before elective congenital heart surgery to see if it lowers postoperative delirium in infants and toddlers (0–36 months) with sleep problems.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing · NCT06879431

• Improving sleep before heart surgery to reduce delirium in young children

  This study is testing if a special bedtime routine can help young children sleep better before heart surgery and reduce the chances of them experiencing confusion afterward.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing · NCT06861998

• Long-term follow-up after Melody heart valve placement

  This follow-up will see how people with congenital heart disease who previously received a Melody valve are doing over the long term.

  Recruiting University Hospital Tuebingen · Tübingen · NCT06845371

• Identifying noninvasive markers of heart transplant rejection in patients with congenital heart disease

  This study is testing a new blood test to see if it can help detect heart transplant rejection in patients with congenital heart disease without needing a more invasive procedure.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06784440

• Collecting skin samples for patients with congenital heart disease

  This study is collecting skin samples from adults with congenital heart disease to help make it easier to find patients for future treatments.

  Recruiting HeartWorks, Inc. · Rochester, Minnesota · NCT06588426

• Comparing cord clamping times for newborns with congenital heart disease

  This study is testing whether clamping the umbilical cord for 30 seconds or 120 seconds after birth helps newborns with congenital heart disease have better health and development.

  Recruiting at 18 sites Nationwide Children's Hospital · Birmingham, Alabama and 20 other locations · NCT06153459

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating how blood flow regulation affects brain development in infants with heart defects

  This study is looking at how the way blood flow to the brain works might affect the growth and development of young children with congenital heart disease, and it aims to find ways to help these kids thrive as they grow up.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-10663932

Related topics

Quick answers

How many Congenital Heart Disease (CHD) clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (6 trials), China (4 trials), Canada (3 trials), Indonesia (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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