Condition

Cleft Lip and Palate clinical trials and research

• 14Clinical trials
• 2NIH research projects
• 9Countries

Newest Cleft Lip and Palate clinical trials

All recruiting trials (14)

• Perceptions of High and Low Intensity Speech Intervention in Children with a Cleft Palate

  This study looks at how providers and children with cleft palate and their parents feel about high- versus low-intensity speech therapy to see which is more acceptable and helpful.

  Recruiting University Ghent · Ghent, East-Flanders · NCT07781566

• Sedation options for suture removal after cleft surgery in young children

  This trial tests whether intramuscular ketamine, intranasal nalbuphine, or intranasal dexmedetomidine provide faster, safer, and more comfortable sedation for children aged 6 months to 3 years during suture removal after cleft surgery.

  Recruiting University Medical Centre Ljubljana · Ljubljana · NCT07340008

• Using clear aligners to expand the upper dental arch in children with cleft lip and palate

  This study is testing if clear aligners can help expand the upper jaw in children aged 6-8 with cleft lip and palate.

  Recruiting Cairo University · Cairo, Select · NCT06994754

• Comparing speech interventions for children with cleft palate

  This study is trying to find out if high or low intensity speech therapy works better for children with cleft palate by talking to the kids, their caregivers, and speech therapists about their experiences.

  Recruiting University Hospital, Ghent · Ghent · NCT06895395

• Comparing single and multiple surgeries for nasal and alveolar repairs in cleft lip and palate patients

  This study is testing whether doing all the necessary nose and gum repairs in one surgery is better than spreading them out over multiple surgeries for kids with cleft lip and palate.

  Recruiting Assiut University · Asyut · NCT06510881

• Using a bioengineered tissue to treat cleft palate in children

  This study is testing a new bioengineered tissue to see if it can help children with cleft palate heal better than the usual surgery.

  Recruiting Phase 1/2 Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental · Granada, Spain/Granada · NCT06408337

• Comparing high and low intensity speech therapy for children with cleft palate

  This study is testing whether more frequent speech therapy sessions help Belgian Dutch-speaking children with cleft palate improve their speech and overall quality of life better than fewer sessions over a longer time.

  Recruiting University Ghent · Ghent · NCT06381713

• Comparing electric and manual toothbrushes for orthodontic patients after oral surgery

  This study tests whether an electric toothbrush works better than a manual toothbrush for improving gum health in orthodontic patients who have had oral surgery.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT06122805

• Evaluating the CLEFT-Q questionnaire for patients with cleft lip and palate

  This study is testing a questionnaire called CLEFT-Q to see how well it works for people with cleft lip and palate in tracking their health and changes after surgery.

  Recruiting Department of Plastic and Reconstructive Surgery · Malmö, Skåne County · NCT05775679

• Using Ketorolac to improve recovery after palatoplasty for cleft lip and palate

  This study tests if giving Ketorolac along with regular pain relief can help patients recover better and eat more easily after surgery for cleft lip and palate.

  Recruiting Phase 4 The University of Texas Health Science Center, Houston · Houston, Texas · NCT04771156

• 3D-printed protective obturators to aid anesthesia for infants with cleft lip and palate

  This trial will test whether custom 3D-printed intraoral obturators made from a preoperative scan can make intubation safer and easier for infants and young children having primary cleft lip or palate surgery.

  Recruiting Brno University Hospital · Brno, Jihomoravská Kraj · NCT04422847

• Evaluating cost effectiveness of bone grafting methods for cleft lip and palate patients

  This study is testing whether new bone grafting methods using BMP and DBM can be more effective and less painful than traditional bone grafts for patients with cleft lip and palate.

  Recruiting Phase 4 The University of Texas Health Science Center, Houston · Houston, Texas · NCT04234971

• Finding genetic causes of cleft lip and palate using whole exome sequencing

  This project will try to find genetic changes that cause non‑syndromic cleft lip and/or palate by sequencing the protein‑coding parts of DNA in patients seen at the Amiens center.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT03065686

• Exploring the genetics of reproductive disorders and cleft lip/palate

  This study is trying to see how genetics might be linked to reproductive disorders and conditions like cleft lip and palate to better understand their causes.

  Recruiting Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud · NCT01601171

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Prenatal gene therapy approach to prevent cleft lip and palate in a human-like mouse model

  The team is trying a prenatal gene-delivery approach in humanized mice to prevent cleft lip and palate linked to TFAP2A mutations, with the goal of helping babies born with those conditions.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11261221

• Rescuing cleft lip and palate before birth using a mouse model

  This study is looking at ways to prevent cleft lip and palate, which are common birth defects, by using special mice to learn more about the genes involved in face development, with the hope of finding new treatments that could help before a baby is born.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11015902

Related topics

Quick answers

How many Cleft Lip and Palate clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Belgium (3 trials), United States (3 trials), Egypt (2 trials), Sweden (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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