Rescuing cleft lip and palate before birth using a mouse model
In utero rescue of cleft lip and palate in a humanized mouse model
This study is looking at ways to prevent cleft lip and palate, which are common birth defects, by using special mice to learn more about the genes involved in face development, with the hope of finding new treatments that could help before a baby is born.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11015902 on NIH RePORTER |
What this research studies
This research investigates how to prevent cleft lip and palate, common birth defects, by using a humanized mouse model. The approach focuses on understanding the genetic factors involved in craniofacial development and how they can be manipulated to improve outcomes. By studying the effects of specific gene mutations, particularly in the TFAP2A gene, researchers aim to develop potential interventions that could be applied during pregnancy. This could lead to innovative therapies that address the underlying causes of these defects before birth.
Who could benefit from this research
Good fit: Ideal candidates for this research are expectant parents with a family history of cleft lip and palate or those identified as at risk due to genetic factors.
Not a fit: Patients who have already been diagnosed with cleft lip and palate and have completed their treatment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventative strategies for cleft lip and palate, improving the quality of life for affected individuals.
How similar studies have performed: Previous research has shown promise in using animal models to understand and potentially intervene in craniofacial development, making this approach both innovative and grounded in existing scientific knowledge.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Williams, Trevor J — University of Colorado Denver
- Study coordinator: Williams, Trevor J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.