Exploring the genetics of reproductive disorders and cleft lip/palate

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the genetic factors associated with various reproductive disorders, including Kallmann syndrome and cleft lip and/or palate. It focuses on understanding how genetic and environmental influences affect puberty and reproductive capacity. The study will analyze the genetic basis of conditions such as hypogonadotropic hypogonadism and polycystic ovarian syndrome, as well as their potential links to cleft lip/palate. By examining these relationships, the research seeks to enhance our understanding of reproductive biology and its genetic underpinnings.

Why it matters

Who can join: the full rules

Inclusion Criteria:(any of the following conditions)

* hypogonadotropic hypogonadism
* Kallmann syndrome
* adult-onset hypogonadotropic hypogonadism
* hypothalamic amenorrhea
* polycystic ovarian syndrome
* primary gonadal failure
* precocious puberty
* cleft lip/palate
* family members of the above groups

Exclusion Criteria:

* acute illness/hospitalization
* pituitary tumors
* iron overload (hemochromatosis)
* infiltrative diseases (sarcoidosis)
* chronic alcohol abuse
* illicit drug use
* anabolic steroid abuse

Where it's running

• Centre Hospitalier Universitaire Vaudois (CHUV)
  Lausanne, Canton of Vaud, Switzerland Recruiting

Study contacts

• Principal investigator: Nelly Pitteloud, M.D. — Centre Hositalier Universitaire Vaudois (CHUV)
• Study coordinator: Emmanuelle Paccou
• Email: emmanuelle.paccou@chuv.ch
• Phone: +41 79 556 60 13

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.