Exploring the genetics of reproductive disorders and cleft lip/palate
The Genetics of Neuroendocrine Reproductive Disorders and of the Cleft Lip and/or Palate
Centre Hospitalier Universitaire Vaudois · NCT01601171
This study is trying to see how genetics might be linked to reproductive disorders and conditions like cleft lip and palate to better understand their causes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire Vaudois (other) |
| Locations | 1 site (Lausanne, Canton of Vaud) |
| Trial ID | NCT01601171 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the genetic factors associated with various reproductive disorders, including Kallmann syndrome and cleft lip and/or palate. It focuses on understanding how genetic and environmental influences affect puberty and reproductive capacity. The study will analyze the genetic basis of conditions such as hypogonadotropic hypogonadism and polycystic ovarian syndrome, as well as their potential links to cleft lip/palate. By examining these relationships, the research seeks to enhance our understanding of reproductive biology and its genetic underpinnings.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with hypogonadotropic hypogonadism, Kallmann syndrome, or related reproductive disorders, as well as their family members.
Not a fit: Patients with acute illnesses, pituitary tumors, or those with a history of substance abuse may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and treatment options for individuals with reproductive disorders and associated conditions.
How similar studies have performed: While the genetic basis of reproductive disorders has been explored in various studies, this specific focus on the overlap with cleft lip/palate is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:(any of the following conditions) * hypogonadotropic hypogonadism * Kallmann syndrome * adult-onset hypogonadotropic hypogonadism * hypothalamic amenorrhea * polycystic ovarian syndrome * primary gonadal failure * precocious puberty * cleft lip/palate * family members of the above groups Exclusion Criteria: * acute illness/hospitalization * pituitary tumors * iron overload (hemochromatosis) * infiltrative diseases (sarcoidosis) * chronic alcohol abuse * illicit drug use * anabolic steroid abuse
Where this trial is running
Lausanne, Canton of Vaud
- Centre Hospitalier Universitaire Vaudois (CHUV) — Lausanne, Canton of Vaud, Switzerland (RECRUITING)
Study contacts
- Principal investigator: Nelly Pitteloud, M.D. — Centre Hositalier Universitaire Vaudois (CHUV)
- Study coordinator: Emmanuelle Paccou
- Email: emmanuelle.paccou@chuv.ch
- Phone: +41 79 556 60 13
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Kallmann Syndrome, Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea, Polycystic Ovarian Syndrome, Precocious Puberty, Cleft Lip and Palate, Cleft Palate, Cleft Lip