AI-guided personalized care for chronic sinus inflammation
Official title: The Chronic Rhinosinusitis (CRS) Problem and an AI Driven Personalized Medicine Solution
Funded at Indiana University Indianapolis · NIH-11249223 · Data updated 2026-11-12
Using AI to personalize treatments for adults with chronic sinus inflammation so people get the therapies most likely to relieve their symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | February 2, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $713,474 |
| NIH project number | 5R01AI175631-03 |
| Project ID | NIH-11249223 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) with ongoing chronic rhinosinusitis who have not had adequate relief from medical therapy or are thinking about surgery.
✕Less likely to help
People under 21, those with a short-term acute sinus infection, or individuals whose symptoms are caused by non-sinus conditions are unlikely to benefit.
What this research studies
You would share your symptoms, medical history, exam findings, and sinus imaging so researchers can build a detailed profile. The team will apply machine learning to find patterns that predict which treatments—like medication changes or surgery—are most likely to help you. That personalized information could be used to guide treatment decisions and track how you respond over time. Participation may include clinic visits, questionnaires, imaging, and sharing relevant health records or samples.
Why it matters
Potential benefit: Could help people with chronic sinus problems get the right treatment faster, improve symptoms, and avoid unnecessary procedures.
How similar studies have gone: Prior work using clinical and imaging markers has shown some ability to predict treatment outcomes, but fully AI-driven personalized prediction for CRS remains a newer and developing approach.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Ramakrishnan, Vijay — Indiana University Indianapolis
- Study coordinator: Ramakrishnan, Vijay
Related research
Other NIH-funded projects on the same topics.
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Using AI to create personalized treatments for chronic rhinosinusitis.
This study is looking at how we can use artificial intelligence to create personalized treatment plans for people with chronic rhinosinusitis (CRS) to help improve their symptoms and overall health.
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Triamcinolone-loaded nanocapsules after endoscopic nasal surgery
This trial tests whether a triamcinolone acetonide–loaded nanocapsule spray is better than saline irrigation for healing after endoscopic nasal surgery in adults with chronic rhinosinusitis and nasal polyps.
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Smell training in CRS patients with smell loss
This study tests whether a 3-month smell training program can improve smell function and related immune and mental health measures in adults with chronic rhinosinusitis and smell loss.
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PROPEL corticosteroid‑releasing sinus implants — IBUKI cohort
This project tests how safe and well PROPEL corticosteroid‑releasing sinus implants work for people in Japan with chronic rhinosinusitis who undergo endoscopic sinus surgery.
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Lavender aromatherapy for anxiety and pain during awake ear, nose, and throat procedures
This tests whether lavender aromatherapy used during awake ear, nose, and throat clinic procedures can reduce anxiety and pain in adults.
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Seawater nasal sprays for relief of nasal and sinus symptoms
This project will test four seawater nasal sprays to see if they help infants, children, adults, and pregnant or breastfeeding people with acute or chronic nasal and sinus symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.