Comparing Penthrox to placebo for pain relief in sinus procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, placebo-controlled trial evaluates the effectiveness of inhaled methoxyflurane (Penthrox) as an analgesic for patients undergoing minor sinus and rhinology procedures, such as Endoscopic Sinus Surgery (ESS) and coblation. Participants will inhale either Penthrox or a placebo during their procedure and will be assessed for pain relief using the Visual Analog Scale (VAS), as well as for anxiety and complications. The study aims to determine if Penthrox provides superior pain relief compared to placebo, potentially improving patient comfort during these procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 19 years or older
* Scheduled for minor sinus surgery or coblation procedures

Exclusion Criteria:

* Cystic fibrosis
* Systemic vasculitis or other bleeding disorders
* History of renal failure or severe kidney disease
* History of liver failure or severe liver disease
* Altered state of consciousness (head injury, alcohol use, drug use)
* Known or suspected hypersensitivity to lidocaine or sensorcaine
* Inhaled drug use (i.e., cocaine) in the preceding 6 months
* Nasal tumors
* Personal or family history of malignant hyperthermia
* Respiratory depression

Where it's running

• St Paul's Sinus Centre
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Study coordinator: Amin Javer, MD
• Email: sinusdoc@me.com
• Phone: 604-806-9926

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.