Condition

Solid Tumor Malignancies clinical trials and research

• 25Clinical trials
• 1New in 30 days
• 6Countries

Newest Solid Tumor Malignancies clinical trials

All recruiting trials (25)

• LB-208: a new oral treatment for adults with advanced solid tumors or lymphoma

  This early study tests whether LB-208, taken once daily by mouth, is safe for adults with advanced solid tumors or lymphoma who have exhausted standard treatments.

  Recruiting Phase 1 Leukos Biotech S.L. · Barcelona, Barcelona · NCT07914348

• Pralsetinib Drug Interaction Study in RET Fusion/MUTATION Positive Solid Tumors

  This trial tests whether pralsetinib changes how the body processes certain medicines in adults with RET fusion- or mutation-positive advanced solid tumors.

  Recruiting at 2 sites Phase 4 Rigel Pharmaceuticals · Logroño, La Rioja and 1 other locations · NCT07704658

• Imaging with 89Zr-DFO-YS5 to detect cancer

  This study tests a new PET radiotracer, 89Zr-DFO-YS5, to see if it can show cancer sites in adults with nerve sheath tumors, bladder cancer, or other solid tumors.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT07664397

• Olutasidenib drug interaction testing for IDH1‑mutant cancers

  This trial tests whether the cancer drug olutasidenib changes how the body processes other medicines in adults with IDH1‑mutation positive cancers.

  Recruiting at 2 sites Phase 4 Rigel Pharmaceuticals · Orange, California and 1 other locations · NCT07486713

• Spinal fluid and blood liquid biopsy for people with metastatic solid tumors with or without brain involvement

  This will test whether a one-time spinal fluid (CSF) and blood sample can find tumor DNA in people with metastatic solid tumors, including those with brain metastases or leptomeningeal disease.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07476781

• Sodium thiosulfate to protect hearing during cisplatin therapy in adults with solid tumors

  This study tests Pedmark sodium thiosulfate to see if it reduces hearing loss in adults receiving standard cisplatin chemotherapy.

  Recruiting Phase 1/2 University of Arizona · Tucson, Arizona · NCT07407582

• SH009 injection for advanced solid tumors

  This trial will test whether SH009 injections are safe and can shrink or slow advanced solid tumors in adults with cancers such as liver, lung, breast, head and neck, and esophageal cancer who have progressed after prior treatment.

  Recruiting Phase 1 Nanjing Sanhome Pharmaceutical, Co., Ltd. · Shanghai · NCT07390838

• SWA1211 tablets for people with advanced solid tumors.

  This first-in-human study will test whether SWA1211 tablets are safe, how the body processes them, and whether they show early anti-tumor activity in adults with advanced solid tumors who have exhausted standard treatments.

  Recruiting Phase 1 Beijing StoneWise Technology Co., Ltd · Shanghai, Shanghai Municipality · NCT07363967

• Valemetostat for selected solid tumors with SWI/SNF gene alterations

  This trial will test whether valemetostat, an EZH1/2 inhibitor, can slow or stop growth in adults whose progressive solid tumors have specific SWI/SNF‑related gene changes.

  Recruiting Phase 2 Gustave Roussy, Cancer Campus, Grand Paris · Villejuif, Val de Marne and 3 other locations · NCT07303387

• Using patient tumor tissue fragments to test drugs and guide treatment for previously treated cancers

  This will test whether growing tiny pieces of a patient's tumor and exposing them to different cancer drugs can help pick better treatments for people with advanced cancers who have already had prior therapy.

  Recruiting Phase 2 Qilu Hospital of Shandong University · Jinan, Shandong · NCT07264803

• SXRN injection for cancer-related anorexia-cachexia

  This trial will see if SXRN injection is safe and can improve appetite, weight, or inflammation in adults with advanced solid tumors who have cancer-associated anorexia-cachexia.

  Recruiting Phase 1 Jiangsu Nutai Biologics Co., Ltd · Beijing, Beijing Municipality · NCT07231120

• KQB548 for advanced solid tumors with a KRAS G12D mutation

  This trial will test whether KQB548 can shrink tumors and is safe in adults with advanced pancreatic, colorectal, or non-small cell lung cancer that have a KRAS G12D mutation after prior therapy.

  Recruiting at 13 sites Phase 1 Kumquat Biosciences Inc. · La Jolla, California and 12 other locations · NCT07207707

• Predicting immune-related side effects in solid cancers treated with immune therapy

  This study tests whether a baseline biological signature can predict immune-related adverse events in adults with solid tumors who are starting immune checkpoint inhibitors.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT07192315

• TJ101 for adults with advanced or metastatic solid tumors: finding a safe dose and checking for tumor response

  This trial tests TJ101, an experimental antibody‑drug given by IV, to see if it is safe and can shrink tumors in adults with advanced or metastatic solid cancers who have run out of standard treatment options.

  Recruiting at 4 sites Phase 1 Phrontline Biopharma · Orlando, Florida and 6 other locations · NCT07181473

• Comparing immune side effects of higher versus lower dosing schedules of pembrolizumab and nivolumab for solid tumors

  This trial will test whether higher-dose, less-frequent pembrolizumab or nivolumab causes more immune-related side effects than lower-dose, more-frequent dosing in adults with solid tumors.

  Recruiting Phase 3 University of Kansas Medical Center · Westwood, Kansas · NCT07174453

• xDRIVE personalized tumor testing for Florida cancer patients

  This program will try a functional precision medicine and AI platform (xDRIVE) to help guide next treatment options for Florida patients with recurrent or refractory cancer, including children and people from underserved communities.

  Recruiting First Ascent Biomedical Inc. · Miami, Florida and 1 other locations · NCT07167381

• GO306 treatment for advanced solid tumors

  This trial tests whether injections of GO306, an oncolytic vaccinia virus, are safe and might help adults with advanced solid tumors that have not responded to standard treatments.

  Recruiting at 6 sites Phase 1 GeneSail Biotech (Shanghai) Co., Ltd. · Hefei, Anhui and 5 other locations · NCT07128914

• DC50292A tablets for MTAP-deleted advanced or metastatic solid tumors

  This trial tests whether daily DC50292A tablets are safe, reach useful blood levels, and may help adults with advanced or metastatic solid tumors that lack MTAP.

  Recruiting at 8 sites Phase 1 Heronova Pharmaceuticals · Fuzhou, Fujian and 7 other locations · NCT07071090

• 18F-G1 PET/CT to see early immunotherapy response in solid tumors and blood cancers

  We are testing if the 18F-G1 PET/CT scan can help tell early on whether people with solid tumors or blood cancers will respond to immunotherapy.

  Recruiting Peking University First Hospital · Beijing · NCT07039474

• CP-383 for advanced or metastatic solid tumors

  This trial tests whether the oral drug CP-383 can slow or stop growth in adults with advanced or metastatic solid tumors who have exhausted standard treatments.

  Recruiting at 13 sites Phase 1/2 Tasca Therapeutics · Denver, Colorado and 12 other locations · NCT07030257

• KQB168 alone or with pembrolizumab for adults with advanced solid tumors

  This will test whether daily KQB168, alone or together with pembrolizumab, can shrink tumors and is safe for adults with advanced solid cancers that have progressed after prior immunotherapy.

  Recruiting at 15 sites Phase 1 Kumquat Biosciences Inc. · Phoenix, Arizona and 14 other locations · NCT06994806

• Evaluating VIR-5525 and its combination with Pembrolizumab for advanced solid tumors

  This study is testing a new treatment called VIR-5525, alone and with another drug called pembrolizumab, to see if it can help people with advanced solid tumors that have a specific protein called EGFR.

  Recruiting at 4 sites Phase 1 Vir Biotechnology, Inc. · Scottsdale, Arizona and 3 other locations · NCT06960395

• Precision oncology navigation with expert genomic review to guide therapy and survival

  This tests whether a centralized precision oncology navigator and expert review of NGS results increase the use of genome-informed therapies for people with stage IV breast, lung, colorectal, or bladder cancer.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06896162

• Investigating KQB365 for treating advanced solid tumors

  This study tests if a new treatment called KQB365, alone or with another drug, can help adults with advanced solid tumors that have specific genetic mutations.

  Recruiting at 11 sites Phase 1 Kumquat Biosciences Inc. · Phoenix, Arizona and 10 other locations · NCT06720987

• Evaluating a new oral drug for advanced solid tumors

  This study is testing a new oral drug called AO-252 to see if it can safely help people with advanced solid tumors, like triple negative breast cancer, ovarian cancer, and endometrial cancer, who haven't had success with other treatments.

  Recruiting at 6 sites Phase 1 A2A Pharmaceuticals Inc. · Detroit, Michigan and 5 other locations · NCT06136884

Related topics

Quick answers

How many Solid Tumor Malignancies clinical trials are recruiting right now?

25, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (13 trials), China (8 trials), Spain (2 trials), France (2 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 13, Phase 4: 2, Phase 1/2: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →