Genetic changes and target genes in adenoid cystic carcinoma
Mutations and Target Genes in Adenoid Cystic Carcinoma
['FUNDING_R01'] · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · NIH-11294168
Researchers are analyzing genetic changes in adenoid cystic carcinoma tumors to find gene targets that could lead to better tests and treatments for people with ACC.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR (nih funded) |
| Locations | 1 site (ALBUQUERQUE, UNITED STATES) |
| Trial ID | NIH-11294168 on ClinicalTrials.gov |
What this research studies
This project looks at tumor tissue and cell samples to find mutations and gene changes linked to adenoid cystic carcinoma, with special focus on the MYB gene and its fusions. Scientists use genomic sequencing and bioinformatics to compare tumors that have MYB-NFIB fusions with those that do not. The work includes examining tumor samples from different body sites where ACC can arise, such as salivary glands, lacrimal glands, breast, and skin. Findings aim to point to biomarkers or molecular targets that could guide future therapies or follow-up strategies.
Who could benefit from this research
Good fit: People diagnosed with adenoid cystic carcinoma (including salivary gland, lacrimal gland, breast, or skin ACC) who can provide tumor tissue or medical records would be the ideal candidates to contribute.
Not a fit: Patients with other cancer types or those unable or unwilling to provide tissue samples are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, the work could reveal biomarkers and gene targets that help tailor treatments or predict who is at higher risk of recurrence or metastasis.
How similar studies have performed: Prior research has already identified MYB-NFIB fusions in many ACC tumors, so this work builds on known findings while addressing tumor types that remain less understood.
Where this research is happening
ALBUQUERQUE, UNITED STATES
- UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR — ALBUQUERQUE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PALANISAMY, VISWANATHAN — UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- Study coordinator: PALANISAMY, VISWANATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.