Clinical trial Recruiting at 1 site Interventional Ages 25 and up

Zirconia dental implants for missing premolars

Official title: Comparison of Two-piece Zirconia Implants With Tissue-level and Bone-level Platform: Randomized Controlled Clinical Trial

Run by University of Ljubljana · NCT06012071 · Data updated 2026-11-12

This study is testing two types of zirconia dental implants for people with missing premolars to see which one works better for long-term health and stability.

Quick facts

Study typeInterventional
Ages25 Years and up
SexAll
Enrollment24 (estimated)
SponsorUniversity of Ljubljana
Academic / other
Locations1 site (Ljubljana)
StatusRecruiting
StartedJuly 3, 2022
Main results expectedJuly 3, 2026
Study endsDecember 3, 2027
Registry record updatedMay 6, 2026
Trial IDNCT06012071 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals with a single missing maxillary premolar, good oral hygiene, and overall good health.

Probably not a fit

Patients with oral mucosa pathology, dental caries, untreated active periodontitis, or systemic diseases affecting healing may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial involves 24 patients with missing premolar teeth who will be randomly assigned to receive either tissue-level or bone-level zirconia implants. The implants will be 10-mm long and 4-mm wide, and their stability will be assessed using the International Stability Quotient (ISQ) device. After a three-month healing period, ceramic crowns will be placed on the implants, and various parameters related to implant survival and peri-implant health will be monitored over a period of 1, 3, and 5 years.

Why it matters

Potential benefit: If successful, this study could improve the outcomes of dental implant procedures for patients with missing premolars.

How similar studies have gone: While there have been studies on zirconia implants, this specific comparison of tissue-level versus bone-level implants is a novel approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Single missing maxillary premolar
* Occlusal stability
* Good oral hygiene
* Good general health

Exclusion Criteria:

* Oral mucosa pathology
* Dental caries
* Active periodontitis (non-treated)
* Systemic diseases and conditions that affect healing or immune capacity

Where it's running

  • University Medical Centre
    Ljubljana, Slovenia
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.