Zirconia dental implants for missing premolars

Comparison of Two-piece Zirconia Implants With Tissue-level and Bone-level Platform: Randomized Controlled Clinical Trial

Not applicable Interventional University of Ljubljana · NCT06012071

This study is testing two types of zirconia dental implants for people with missing premolars to see which one works better for long-term health and stability.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment24 (estimated)
Ages25 Years and up
SexAll
SponsorUniversity of Ljubljana Academic / other
Locations1 site (Ljubljana)
Trial IDNCT06012071 on ClinicalTrials.gov

What this trial studies

This clinical trial involves 24 patients with missing premolar teeth who will be randomly assigned to receive either tissue-level or bone-level zirconia implants. The implants will be 10-mm long and 4-mm wide, and their stability will be assessed using the International Stability Quotient (ISQ) device. After a three-month healing period, ceramic crowns will be placed on the implants, and various parameters related to implant survival and peri-implant health will be monitored over a period of 1, 3, and 5 years.

Who should consider this trial

Good fit: Ideal candidates include individuals with a single missing maxillary premolar, good oral hygiene, and overall good health.

Not a fit: Patients with oral mucosa pathology, dental caries, untreated active periodontitis, or systemic diseases affecting healing may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve the outcomes of dental implant procedures for patients with missing premolars.

How similar studies have performed: While there have been studies on zirconia implants, this specific comparison of tissue-level versus bone-level implants is a novel approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Single missing maxillary premolar
* Occlusal stability
* Good oral hygiene
* Good general health

Exclusion Criteria:

* Oral mucosa pathology
* Dental caries
* Active periodontitis (non-treated)
* Systemic diseases and conditions that affect healing or immune capacity

Where this trial is running

Ljubljana

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Edentulous Alveolar Ridgedental implantszirconiatwo-piece
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.