Zirconia dental implants for missing premolars
Official title: Comparison of Two-piece Zirconia Implants With Tissue-level and Bone-level Platform: Randomized Controlled Clinical Trial
Run by University of Ljubljana · NCT06012071 · Data updated 2026-11-12
This study is testing two types of zirconia dental implants for people with missing premolars to see which one works better for long-term health and stability.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years and up |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | University of Ljubljana Academic / other |
| Locations | 1 site (Ljubljana) |
| Status | Recruiting |
| Started | July 3, 2022 |
| Main results expected | July 3, 2026 |
| Study ends | December 3, 2027 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT06012071 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with a single missing maxillary premolar, good oral hygiene, and overall good health.
✕Probably not a fit
Patients with oral mucosa pathology, dental caries, untreated active periodontitis, or systemic diseases affecting healing may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial involves 24 patients with missing premolar teeth who will be randomly assigned to receive either tissue-level or bone-level zirconia implants. The implants will be 10-mm long and 4-mm wide, and their stability will be assessed using the International Stability Quotient (ISQ) device. After a three-month healing period, ceramic crowns will be placed on the implants, and various parameters related to implant survival and peri-implant health will be monitored over a period of 1, 3, and 5 years.
Why it matters
Potential benefit: If successful, this study could improve the outcomes of dental implant procedures for patients with missing premolars.
How similar studies have gone: While there have been studies on zirconia implants, this specific comparison of tissue-level versus bone-level implants is a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Single missing maxillary premolar * Occlusal stability * Good oral hygiene * Good general health Exclusion Criteria: * Oral mucosa pathology * Dental caries * Active periodontitis (non-treated) * Systemic diseases and conditions that affect healing or immune capacity
Where it's running
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University Medical Centre
Ljubljana, Slovenia Recruiting
Study contacts
- Principal investigator: Rok Gašperšič, PhD — faculty of medicine
- Study coordinator: Rok Gašperšič, PhD
- Email: rok.gaspersic@mf.uni-lj.si
- Phone: 0038615224998
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.