Freeze-dried donor bone versus your own bone to widen the jaw for dental implants
Official title: Comparison of Freeze-dried Bone Allograft and Autogenous Bone Blocks in the Surgical Reconstruction of Horizontally Atrophied Jaws for Implant Placement: Randomized Clinical Trial
Run by Semmelweis University · NCT07104370 · Data updated 2026-11-12
This test will see if freeze-dried donor bone blocks work as well as a person's own bone blocks to rebuild the jaw for dental implants in adults with significant ridge atrophy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Semmelweis University Academic / other |
| Locations | 1 site (Budapest, Hungary) |
| Status | Recruiting |
| Started | September 29, 2025 |
| Main results expected | September 1, 2028 |
| Study ends | September 1, 2033 |
| Registry record updated | October 3, 2025 |
| Trial ID | NCT07104370 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with lateral alveolar ridge atrophy who require lateral augmentation for implant rehabilitation and who meet the study's health and non-smoking criteria.
✕Probably not a fit
Patients who smoke, are pregnant, have poor oral hygiene, recent head and neck irradiation, systemic illnesses or medications that affect bone metabolism, or psychiatric contraindications are excluded and unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional comparison enrolls adults with lateral alveolar ridge atrophy who need bone augmentation before dental implant placement. Participants receive either an autologous bone block harvested from the retromolar area or a freeze-dried allograft block, with preoperative and postoperative CBCT imaging to measure bone changes. Dental implants are placed after augmentation and outcomes such as graft success, bone volume maintenance, and implant survival are followed at scheduled visits. Key exclusions include smoking, pregnancy, poor oral hygiene, prior head and neck irradiation, medications affecting bone metabolism, and systemic or psychiatric conditions that contraindicate implant rehabilitation.
Why it matters
Potential benefit: If successful, using freeze-dried allograft blocks could reduce surgical time and donor-site morbidity while providing sufficient bone volume for reliable dental implant placement.
How similar studies have gone: Block allografts have been reported to work reasonably well in prior clinical series, but autologous bone remains the gold standard because it preserves osteogenic properties.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * over 18 years old * require lateral augmentation for implant rehabilitation Exclusion Criteria: * Smoking * Pregnancy * Poor oral hygiene * Failure to attend follow-up visits * Therapeutic-dose irradiation to the head and neck region * Local bone tumors, cysts, or inflammatory processes * Decompensated systemic diseases contraindicate surgery * Use of medications affecting bone metabolism (steroids, antiresorptive medications such as bisphosphonates, RANKL inhibitor antibodies, VEGF antagonists) * Psychiatric disorders contraindicate implant rehabilitation
Where it's running
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Semmelweis University Department of Public Dental Health
Budapest, Hungary, Hungary Recruiting
Study contacts
- Principal investigator: Csilla Szerencse, DMD, MDS — Department of Public Dental Health Semmelweis University
- Study coordinator: Csilla Szerencse, DMD, MDS
- Email: szerencse.csilla@semmelweis.hu
- Phone: 003614591500
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.