Freeze-dried donor bone versus your own bone to widen the jaw for dental implants
Comparison of Freeze-dried Bone Allograft and Autogenous Bone Blocks in the Surgical Reconstruction of Horizontally Atrophied Jaws for Implant Placement: Randomized Clinical Trial
This test will see if freeze-dried donor bone blocks work as well as a person's own bone blocks to rebuild the jaw for dental implants in adults with significant ridge atrophy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Semmelweis University Academic / other |
| Locations | 1 site (Budapest, Hungary) |
| Trial ID | NCT07104370 on ClinicalTrials.gov |
What this trial studies
This interventional comparison enrolls adults with lateral alveolar ridge atrophy who need bone augmentation before dental implant placement. Participants receive either an autologous bone block harvested from the retromolar area or a freeze-dried allograft block, with preoperative and postoperative CBCT imaging to measure bone changes. Dental implants are placed after augmentation and outcomes such as graft success, bone volume maintenance, and implant survival are followed at scheduled visits. Key exclusions include smoking, pregnancy, poor oral hygiene, prior head and neck irradiation, medications affecting bone metabolism, and systemic or psychiatric conditions that contraindicate implant rehabilitation.
Who should consider this trial
Good fit: Adults over 18 with lateral alveolar ridge atrophy who require lateral augmentation for implant rehabilitation and who meet the study's health and non-smoking criteria.
Not a fit: Patients who smoke, are pregnant, have poor oral hygiene, recent head and neck irradiation, systemic illnesses or medications that affect bone metabolism, or psychiatric contraindications are excluded and unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, using freeze-dried allograft blocks could reduce surgical time and donor-site morbidity while providing sufficient bone volume for reliable dental implant placement.
How similar studies have performed: Block allografts have been reported to work reasonably well in prior clinical series, but autologous bone remains the gold standard because it preserves osteogenic properties.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * over 18 years old * require lateral augmentation for implant rehabilitation Exclusion Criteria: * Smoking * Pregnancy * Poor oral hygiene * Failure to attend follow-up visits * Therapeutic-dose irradiation to the head and neck region * Local bone tumors, cysts, or inflammatory processes * Decompensated systemic diseases contraindicate surgery * Use of medications affecting bone metabolism (steroids, antiresorptive medications such as bisphosphonates, RANKL inhibitor antibodies, VEGF antagonists) * Psychiatric disorders contraindicate implant rehabilitation
Where this trial is running
Budapest, Hungary
- Semmelweis University Department of Public Dental Health — Budapest, Hungary, Hungary (Recruiting)
Study contacts
- Principal investigator: Csilla Szerencse, DMD, MDS — Department of Public Dental Health Semmelweis University
- Study coordinator: Csilla Szerencse, DMD, MDS
- Email: szerencse.csilla@semmelweis.hu
- Phone: 003614591500
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.