When and how much fluid to remove in critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, prospective observational cohort of adult ICU patients who have a treating-physician–determined indication for deresuscitation. Clinical data, point-of-care ultrasound measures, and laboratory and metabolic profiles will be collected during the first attempt at deresuscitation. The primary outcome is successful deresuscitation, defined as achieving a negative fluid balance within 24 hours without hemodynamic consequences, with secondary work on timing, rate (dose) and subgroup differences (sepsis, ARDS, cardiac patients). Analyses will explore predictors of diuretic and ultrafiltration response, optimal individualized deresuscitation rates, and associations with complications such as electrolyte/acid–base disturbances, hemodynamic instability, atrial fibrillation, and delirium.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Admission to one of the participating ICUs;
* Clinical indication for deresuscitation using diuretics or ultrafiltration as set by the treating physician; first attempt during the ICU stay.

Exclusion Criteria:

* Age below 18 years old;
* Major cardiac shunts;
* Moderate to severe aortic regurgitation;
* Morbid Obesisty (BMI \>40);
* POCUS impossible or unreliable (i.e. pre-existing interstitial lung disease);
* PLR or modified form of PLR impossible (i.e. ECMO);
* Transfer from another ICU;
* Previous inclusion in this study;
* Patients who are moribund or facing the end of life;
* Opt out.

Where it's running

• Olvg
  Amsterdam, Netherlands Recruiting
• Amsterdam UMC
  Amsterdam, Netherlands Recruiting

Study contacts

• Study coordinator: Krijna Opschoor, MD
• Email: k.opschoor@amsterdamumc.nl
• Phone: +31 (0)20 566 9111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.