Personalized High-Rate Fluid Removal Guided by Ultrasound in Hospitalized ESRD with Fluid Overload

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares a personalized, ultrasound-guided high-rate ultrafiltration strategy to standard fluid removal in adults with end-stage renal disease requiring hospital-based fluid removal for acute congestion. Ultrasound techniques, including lung ultrasound and VExUS, are used to identify patients with severe intravascular congestion and guide treatment. The goal is to determine if rapid fluid removal can relieve symptoms without increasing risk compared with conventional rates. The study is conducted at a tertiary center in Monterrey, with collaboration between Universidad Autonoma de Nuevo Leon and Hospital Universitario Dr. Jose E. Gonzalez. Participants are adults on long-term hemodialysis, hemodynamically stable at baseline, and meeting ultrasound-confirmed congestion criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults over 18 years old with End-Stage Renal Disease on hemodialysis for at least 3 months.
* Admitted to the hospital requiring mechanical fluid removal for acute fluid overload (first in-hospital session).
* Clear ultrasound evidence of severe intravascular congestion (such as diffuse B-lines in the lungs or altered VExUS vascular flow patterns).
* Hemodynamically stable with a baseline blood pressure of at least 120/80 mmHg.

Exclusion Criteria:

* Baseline low blood pressure (\<100/60 mmHg) or active shock (cardiogenic, septic, or distributive).
* Acute coronary syndrome (heart attack), severe heart valve disease, or severe fluid around the heart.
* Known chronic lung disease.
* Pregnancy.

Where it's running

• Hospital Universitario "Dr. José E. González"
  Monterrey, Nuevo León, Mexico Recruiting

Study contacts

• Study coordinator: Edgar Adrián Montemayor, Nephrology Fellow
• Email: edgar.montemayorga@uanl.edu.mx
• Phone: +52 8180911271

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.