Venous findings in lipedema: how vein health relates to pain and function
Official title: Evaluation of Venous Insufficiency and Its Association With Clinical Features in Patients With Lipedema: A Cross-Sectional Study
Run by Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · NCT07603076 · Data updated 2026-11-12
This study tests whether venous insufficiency seen on Doppler ultrasound is more common in people with lipedema and how it relates to pain, function, and quality of life.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | Women only |
| Enrollment | 82 (estimated) |
| Sponsor | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Academic / other |
| Locations | 1 site (Istanbul, Uskudar) |
| Status | Recruiting |
| Started | June 20, 2026 |
| Main results expected | July 30, 2026 |
| Study ends | August 1, 2026 |
| Registry record updated | July 14, 2026 |
| Trial ID | NCT07603076 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women 18 years or older with clinically diagnosed lipedema who can consent and complete assessments.
✕Probably not a fit
Individuals without venous abnormalities on Doppler or with conditions that confound venous assessment may not see a direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This cross-sectional observational study will use venous Doppler ultrasonography to assess venous reflux, diameters, and affected segments in women with lipedema. It will analyze associations between these vascular findings and pain severity, lower-extremity function, lipedema severity, anthropometrics, and patient-reported outcomes. Participants will complete numeric pain ratings, the Lower Extremity Functional Scale, and the SF-12, along with standardized circumference measurements. The goal is to better understand the role of venous involvement in lipedema and inform more comprehensive diagnostic and management approaches.
Why it matters
Potential benefit: If venous insufficiency is linked to worse symptoms, this could guide more targeted assessment and multidisciplinary care for lipedema.
How similar studies have gone: Other studies have shown that venous involvement can relate to symptom burden in lipedema, but findings are still evolving and this study adds focused Doppler data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female participants aged 18 years or older * Clinically diagnosed lipedema according to established diagnostic criteria * Ability to provide written informed consent * Ability to complete clinical assessments and questionnaires Exclusion Criteria: * History of lower extremity venous surgery or sclerotherapy * Known peripheral arterial disease * Secondary lymphedema or other causes of lower extremity edema * Active infection, cellulitis, or inflammatory disease affecting the lower extremities * Pregnancy or postpartum period * Neurological, rheumatological, or musculoskeletal disorders significantly affecting lower extremity function * Malignancy or severe systemic disease * Inability to undergo venous Doppler ultrasonography * Inability to understand or complete study assessments and questionnaires
Where it's running
-
Department of Physical Medicine and Rehabilitation, Health Sciences University Sultan Abdulhamid Han Training and Research Hospital
Istanbul, Uskudar, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Feyza Yücel, Assoc. Prof. — Sultan 2.Abdülhamid Han Research and Training Hospital
- Study coordinator: Feyza Yücel, Assoc. Prof.
- Email: dr.fny28@gmail.com
- Phone: (0216) 542 20 00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.