taVNS-enriched rehab for lipedema

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with lipedema will be randomized to receive either taVNS plus aerobic exercise and complex decongestive therapy (CDT) or sham taVNS with the same rehabilitation. The trial assesses whether taVNS can lower inflammation and improve pain and function as part of a multimodal treatment. The design focuses on a comparison between taVNS-enhanced rehabilitation and conventional rehabilitation in adult women. The study is conducted at Bezmialem Vakif University in Istanbul with lead sponsorship from Istanbul University - Cerrahpasa.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female participants aged 18-65 years.
* Clinical diagnosis of lipedema confirmed by a specialist physician.
* Bilateral and symmetrical disproportionate adipose tissue accumulation in the lower extremities.
* Pain or tenderness on pressure in the affected areas.
* Negative Stemmer's sign.
* Willingness to participate in the study and provision of written informed consent.

Exclusion Criteria:

* Secondary or iatrogenic obesity due to endocrine disorders or medication use.
* Body weight change greater than 10% within the previous six months.
* Initiation or modification of estrogen-progestin therapy within the previous two months.

Where it's running

• Bezmialem Vakif University
  Istanbul, Eyupsultan, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: merve sevinç gündüz, MSc
• Email: mrvsevinccc@gmail.com
• Phone: 05312991841

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Kinesio Taping Added to Standard Care for Women with Lipedema

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• Comparison of body composition in lipedema and obesity

  This study tests whether women with lipedema have different segmental body fat and muscle distribution compared with BMI-matched women without lipedema.

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• Comparison of Different Exercise Protocols for Lipedema

  This study tests whether high‑intensity interval training or moderate‑intensity continuous training improves function, strength, and quality of life in adults with lipedema.

  Recruiting Hitit University · Çorum · NCT07873541

• Manual and self-lymphatic drainage with exercise for lipedema

  This study tests whether manual lymph drainage plus supervised exercise works better than self-lymph drainage plus guided activity for reducing pain and improving function in women with lipedema over six weeks.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Eyupsultan · NCT07803926

• Turkish version of the Duke Activity Status Index in women with lipedema

  This study tests whether the Turkish Duke Activity Status Index accurately and consistently measures functional capacity in women with lipedema.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Eyupsultan · NCT07803913

• Aquatic vs. land-based exercise for lipedema in women

  This trial tests whether supervised pool workouts or equivalent land-based exercise improve walking ability and symptoms more than standard care for women with lipedema.

  Recruiting Cairo University · Giza, Dokki · NCT07756463

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.