Using SGLT2 inhibitors to improve heart function after a heart attack

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to evaluate the effectiveness of SGLT2 inhibitors in enhancing heart function and reducing heart enlargement in patients who have experienced their first STEMI. Participants will take either the medication or a placebo daily for six months, undergo cardiac MRI testing during hospitalization and at the six-month follow-up, and receive phone check-ins at one and three months. The study focuses on patients with mild left ventricular dysfunction following successful primary PCI. It is a single-center, interventional Phase 2 trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with their first STEMI (\>18 years) who underwent successful primary PCI and able to give informed consent
* At least mild LV dysfunction (LVEF \< 50%) on echocardiogram, cMRI or Left Ventriculargram following PCI
* Infarct size that is \> 10% of LV mass
* The presence of MVO that is \> 10% of infarct size

Exclusion Criteria:

* Contraindication to cardiac MRI
* Life expectancy \< 1 year
* Previous CABG or Valve Surgery
* Previous STEMI
* Pregnant or planning to become pregnant or lactating women
* Cardiogenic shock (not resolved)
* Atrial fibrillation or recurrent sustained ventricular arrhythmias (excluding PVCs)
* GFR\<30 ml/min/1.73m2 or end-stage renal disease on dialysis
* Type 1 diabetes mellitus or history of diabetic ketoacidosis
* Type I or II diabetes with insulin use
* Prior intolerance of SGLT2 inhibitors
* Current use of SGLT2 inhibitors (randomized patients only)
* Contraindications to gadolinium

Where it's running

• Minneapolis Heart Institute Foundation
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Jay Traverse, MD — Minneapolis Heart Institute Foundation
• Study coordinator: Sarah Schwager, RN
• Email: sarah.schwager@allina.com
• Phone: 612-863-3833

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.