Using rTMS to treat dyskinesia caused by Parkinson's medication

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in treating levodopa-induced dyskinesia (LID) in patients with Parkinson's Disease. It focuses on delivering patterned stimulation to the pre-supplementary motor area to delay the onset of LID and reduce its severity. The study aims to optimize stimulation parameters based on individual neuroanatomy and explore the impact of high-frequency bursts of rTMS. By targeting specific brain regions, the research seeks to provide insights into the mechanisms of LID and improve treatment outcomes for affected patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinically established or probable PD
* Clinical Diagnostic Criteria for Parkinson's Disease
* Peak-of-dose levodopa-induced dyskinesia.
* Stable antiparkinsonian medicine for at least four weeks.
* Signed informed consent.

Exclusion Criteria:

* Psychiatric disorders.
* Usage of antipsychotic medication, Donepezil, and GABAergic medications (such as pregabalin and gabapentin).
* Regular usage of benzodiazepines and opioids (more than once per week).
* History of neurological disease other than Parkinson's disease.
* History of epilepsy/conditions associated with increased risk to seizure-induction through TMS.
* Close relatives suffering from epilepsy/conditions associated with increased risk to seizure-induction through TMS.
* Contraindications for MRI scan
* Female participants of childbearing age must not be pregnant and that they must use contraception during the trial.
* Refuse to be informed about new health related information and accidental health related findings that might appear through participation in the study.

Where it's running

• Drcmr
  Hvidovre, Denmark Recruiting

Study contacts

• Principal investigator: Hartwig R. Siebner, Prof. — Head of Research, Prof, DMSc
• Study coordinator: Laura Sakalauskaite, MD
• Email: laura.sakalauskaite.01@regionh.dk
• Phone: +45 38621184

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.