Using NOL to guide pain management during laparoscopic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates whether the nociception level index (NOL) can effectively reduce opioid consumption in adult patients undergoing elective laparoscopic surgeries under general anesthesia. Patients will be randomly assigned to either an intervention group, where NOL is used to guide analgesia, or a control group receiving standard anesthetic care. The study aims to assess the impact of NOL on postoperative pain and recovery outcomes. Standard monitoring and anesthesia protocols will be followed for all participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients undergoing planned laparoscopic surgery under general anesthesia.

Exclusion Criteria:

* Emergency surgery.
* Pregnancy.
* Drug or alcohol abuse in the last 6 months.
* Chronic opioid use or patients with chronic pain.
* Serious comorbidity \[cardiac disease (atrial fibrillation, ventricular arrhythmias), liver or kidney disease\]
* Obesity (BMI \>35).
* Permanently implanted pacemaker.
* Patients with CNS disease.
* Allergy to any of the study drugs.
* Patients receiving anticholinergics agonists, α2-adrenergic agonists, β1-adrenergic antagonists, antiarrhythmic drugs.

Where it's running

• 2nd Department of Anesthesiology, Attikon University Hospital
  Athens, Attica, Greece Recruiting

Study contacts

• Study coordinator: PARASKEVI Prof MATSOTA
• Email: matsota@yahoo.gr
• Phone: 6945544563

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• GLP-1 receptor agonists and dry eye in adults with type 2 diabetes and obesity

  This study tests whether GLP-1 receptor agonists affect dry eye disease in adults with type 2 diabetes and obesity.

  Recruiting Attikon Hospital · Athens · NCT07605572

• Cryoneurolysis before total knee replacement surgery

  This trial will test whether freezing the genicular nerves at least 24 hours before total knee replacement reduces long-term pain and improves recovery for adults having primary TKA for osteoarthritis.

  Recruiting Attikon Hospital · Athens · NCT07425457

• Using EEG in stroke units to find hidden seizures and predict epilepsy

  This project uses routine EEG in adults hospitalized with recent ischemic or hemorrhagic stroke to see if EEG can detect hidden seizures and predict who will develop epilepsy.

  Recruiting Attikon Hospital · Chaïdári, Athens · NCT07190976

• Identifying genetic factors that predict dietary intervention success in IBS

  This study is trying to find out if certain genes can help predict how well people with Irritable Bowel Syndrome will respond to a special diet that combines low FODMAP and Mediterranean foods.

  Recruiting Attikon Hospital · Athens · NCT06912828

• Investigating cardiovascular markers in women with PCOS during glucose testing

  This study is testing how glucose testing affects heart health markers in women with PCOS and whether different treatments can improve those markers over six months.

  Recruiting Attikon Hospital · Chaïdári · NCT06889454

• Digestive enzyme treatment for IBS patients who responded to a low FODMAP diet

  This study is testing if a digestive enzyme can help people with IBS who felt better on a low FODMAP diet but have had their symptoms come back after a year.

  Recruiting at 2 sites Attikon Hospital · Chaïdári, Athens and 1 other locations · NCT06749613

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.