Using NOL to guide pain management during laparoscopic surgery
Ιntraoperative Administration of Opioids Guided by the Nociception Level Index NOL in Elective Laparoscopic Surgeries Under General Anesthesia: Effect on Opioid Consumption, Post-operative Pain and Patient Recovery
This study tests if using a special pain measurement tool can help adults having laparoscopic surgery use fewer opioids and recover better after their procedure.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Attikon Hospital Academic / other |
| Locations | 1 site (Athens, Attica) |
| Trial ID | NCT06104059 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates whether the nociception level index (NOL) can effectively reduce opioid consumption in adult patients undergoing elective laparoscopic surgeries under general anesthesia. Patients will be randomly assigned to either an intervention group, where NOL is used to guide analgesia, or a control group receiving standard anesthetic care. The study aims to assess the impact of NOL on postoperative pain and recovery outcomes. Standard monitoring and anesthesia protocols will be followed for all participants.
Who should consider this trial
Good fit: Ideal candidates are adult patients over 18 years old scheduled for elective laparoscopic surgery under general anesthesia.
Not a fit: Patients who may not benefit include those undergoing emergency surgeries, pregnant individuals, or those with chronic pain or serious comorbidities.
Why it matters
Potential benefit: If successful, this approach could lead to reduced opioid use and improved recovery for patients undergoing laparoscopic surgery.
How similar studies have performed: Other studies have shown promise in using nociception monitoring to guide analgesia, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients undergoing planned laparoscopic surgery under general anesthesia. Exclusion Criteria: * Emergency surgery. * Pregnancy. * Drug or alcohol abuse in the last 6 months. * Chronic opioid use or patients with chronic pain. * Serious comorbidity \[cardiac disease (atrial fibrillation, ventricular arrhythmias), liver or kidney disease\] * Obesity (BMI \>35). * Permanently implanted pacemaker. * Patients with CNS disease. * Allergy to any of the study drugs. * Patients receiving anticholinergics agonists, α2-adrenergic agonists, β1-adrenergic antagonists, antiarrhythmic drugs.
Where this trial is running
Athens, Attica
- 2nd Department of Anesthesiology, Attikon University Hospital — Athens, Attica, Greece (Recruiting)
Study contacts
- Study coordinator: PARASKEVI Prof MATSOTA
- Email: matsota@yahoo.gr
- Phone: 6945544563
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.