Identifying genetic factors that predict dietary intervention success in IBS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify single nucleotide polymorphisms (SNPs) that may influence the response to a combined dietary intervention consisting of a low FODMAP diet and the Mediterranean diet in patients with Irritable Bowel Syndrome (IBS). Blood samples will be collected for DNA extraction, and genotyping will be performed using Next Generation Sequencing (NGS) technology. The study will also assess symptom severity using the IBS-SSS scale and mental health status with the HADS questionnaire. Participants will be recruited from the Department of Clinical Nutrition at Attikon University General Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Fulfillment of the Rome IV criteria for IBS
* Provision of written informed consent.
* Commitment of availability throughout the study period.
* IBS-SSS \> 175

Exclusion Criteria:

* Any concomitant disease requiring specialized nutrition (e.g. renal failure, diabetes, celiac disease, cerebrovascular disease of the central nervous system, major surgical cavity).
* Pregnancy.
* Breastfeeding.

Where it's running

• Attikon General University Hospital of Athens
  Athens, Greece Recruiting

Study contacts

• Study coordinator: Konstantinos Triantafyllou, Proffesor
• Email: ktriant@med.uoa.gr
• Phone: +306977402690

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• IBS-oriented Crohn's Disease Exclusion Diet versus Low FODMAP Diet for IBS

  This study tests whether an IBS-adapted Crohn's Disease Exclusion Diet (CDED) can better help adults with IBS-D or IBS-M than the low FODMAP diet.

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• How certain FODMAPs affect IBS pain in adults

  This study tests whether adding back specific FODMAP types after a low-FODMAP diet can reveal which ones drive abdominal pain in adults with IBS.

  Recruiting Queen's University · Kingston, Ontario · NCT07688044

• Gut–brain gut study in IBS with anxiety and depression

  This study will compare people with IBS and mood symptoms to healthy volunteers to see if gut bacteria relate to brain function using questionnaires, stool and blood samples, and a brain MRI.

  Recruiting Tang-Du Hospital · Xi'an, Shaanxi · NCT07646834

• Pregabalin for irritable bowel syndrome in adults

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  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07635394

• Probiotic combination for irritable bowel syndrome

  This trial will test whether a daily probiotic capsule lowers symptom severity and affects gut transit time in adults with IBS.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT07584278

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.