Using NMN to Improve Embryo Development in IVF Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of Nicotinamide Mononucleotide (NMN) supplementation in enhancing embryo development and increasing success rates in patients who have experienced repeated failures in in vitro fertilization (IVF). The research focuses on the relationship between mitochondrial function and oocyte quality, particularly in women aged 32-42 with a history of low embryo quality. Participants will receive either NMN capsules or a placebo, and the outcomes will be measured based on embryo development capacity and overall IVF success. The study aims to address the challenges posed by reproductive aging and improve fertility outcomes for affected women.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Agree to participate in the study
* 32-42 years old
* Having at least one previous embryo implantation failure
* History of low Embryo quality at day3 or day5 (according to Veeck's and Gardner's Criteria)
* No major uterine or ovarian abnormalities
* BMI level 18-25kg/m2

Exclusion Criteria:

* Ovarian endometriosis with Chocolate cysts (AFS type 3 and 4)
* Patients who have taken different supplements such as coenzyme Q10, vitamin E, carnitine,niacin, nicotinamide, or other vitamin B3-related etc. within the previous month
* Any medical contraindication of oocyte retrieval or subsequent procedures
* Couples where the husband presents with severe sperm abnormalities
* Couples where the husband presents \<5 million/mL motile sperm
* Uterine structural anomalies
* Polycystic ovaries
* Premature ovarian failure
* Individuals who need regular medication to treat chronic diseases such as diabetes, hypertension, gout, hyperuricemia, etc.
* Individuals who need drug treatment for any mental illness such as epilepsy and depression.
* Individuals who suffer from infectious diseases such as hepatitis B, active tuberculosis, AIDS, etc.
* Cancer patients or receiving chemo/radiotherapy treatment within the past 3 years.

Where it's running

• IVF Namba Clinic, Sankaky Medical Corporation
  Osaka, Osaka, Japan Recruiting

Study contacts

• Principal investigator: Yoshiharu M., Yoshiharu Morimoto, MD, PhD — Sankaky Medical Corporation
• Study coordinator: Udayanga KGS., Udayanga Gamage, BVSc, PhD
• Email: udayanga646@ivfjapan.com
• Phone: +81 90 9823 8477

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.