PPOS versus GnRH antagonist IVF protocols for women with PCOS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Women meeting modified Rotterdam criteria for PCOS who are indicated for IVF will receive one of two controlled ovarian stimulation approaches: a progestin-primed ovarian stimulation (PPOS) protocol or a GnRH antagonist protocol. Key IVF outcomes such as number of oocytes retrieved, fertilization and embryo quality, pregnancy rates, and rates of complications (including ovarian hyperstimulation) will be recorded and compared between groups. Eligible participants are 18–40 years old, have PCOS, and a partner with normal or mildly-to-moderately abnormal sperm parameters; major uterine or prior ovarian surgery that impairs outcomes are exclusionary. The protocol is conducted at Hanoi General Hospital with standard IVF monitoring and follow-up visits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18-40 years
* Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound)
* Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI)
* Eligible for controlled ovarian stimulation for IVF
* Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT)
* Willing and able to provide written informed consent and comply with study procedures.

Exclusion Criteria:

* Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology.
* History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy)
* History of recurrent pregnancy loss (≥3 spontaneous miscarriages)
* Known chromosomal abnormalities in either partner
* Inability to adhere to study protocol or follow-up procedures

Where it's running

• Hanoi General Hospital
  Hanoi, Hanoi, Vietnam Recruiting

Study contacts

• Principal investigator: Phuong Duy Nguyen, MD, MS — Hanoi General Hospital
• Study coordinator: Phuong Duy Nguyen, MD, MSc - PI
• Email: nguyenduyphuongncs44@gmail.com
• Phone: +84 986656835

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.