Endometrial immune profile changes after putting your own PRP into the uterus

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional single-site study gives autologous intrauterine platelet-rich plasma (PRP) to people undergoing assisted reproduction and euploid embryo transfer, then measures changes in the endometrial immune cell profile and lining thickness. Investigators will also measure mid-luteal estradiol (E2) and progesterone (P4) levels and track IVF outcomes including biochemical and clinical pregnancy. Patients are screened to exclude uterine pathology, active endometrial infection or inflammation, PCOS, autoimmune disease, recent immune therapy, cancer, or positive HIV/HCV/HBV tests. The study is conducted at Nadezhda Women's Health Hospital in Sofia and compares pre- and post-PRP immune and histologic findings alongside pregnancy outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participating in Assisted Reproduction Treatment
* Having infertility
* Having regular menstrual cycles
* Embryo transfer of euploid embryos

Exclusion Criteria:

* Uterine pathologies
* Endometrial Bacterial infections
* Active endometrial inflammation
* Polycystic ovary syndrome
* Cancer diagnostics
* Positive HIV, HCV or HBV tests
* Autoimmune diseases
* Recent immune therapy

Where it's running

• Nadezhda Women's Health Hospital
  Sofia, Sofia, Bulgaria Recruiting

Study contacts

• Study coordinator: Georgi Stamenov, MD
• Email: g.stamenov@abv.bg
• Phone: +359888269839

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.